1-Bromo-4-Fluorobenzene serves as a halogenated aromatic compound carrying both a bromine and a fluorine atom attached to a benzene ring. In a laboratory, it draws attention for its unique combination of substituents that offer helpful chemical reactivity. The compound’s molecular formula, C6H4BrF, points to its benzene backbone linked to a bromine atom at the 1-position and a fluorine at the 4-position. This straightforward structure makes it a starting point in making pharmaceuticals, agrochemicals, and advanced molecular materials.
On a bench, 1-Bromo-4-Fluorobenzene commonly appears as a colorless liquid with a faint aromatic scent. Chemists and handlers note its density typically stands around 1.553 g/cm³ at 20°C. The melting point sits close to -2°C, while the boiling point ranges from 153°C to 155°C. The refractive index at 20°C clocks in at 1.531. In storage, it appears stable in sealed glass containers, and shipped volumes often arrive in steel drums or amber glass bottles depending on usage and regulatory guidelines. In practical applications, it sometimes presents as a clear, colorless crystal or a liquid, showing versatility across physical states.
Each molecule consists of six carbon atoms arranged in a ring, four hydrogen atoms, a bromine, and a fluorine, summarized with the formula C6H4BrF. A chemist drawing the structure would see bromine sitting at one end of the ring, fluorine directly across, giving rise to para-substitution. This arrangement imparts distinctive chemical properties and reactivity patterns because bromine and fluorine each influence the electronic environment of the benzene ring. In the synthesis of complex active pharmaceutical ingredients, raw materials like this intermediate become critical for specific substitutions and coupling reactions.
Production lines for pharmaceuticals and electronic chemicals often rely on 1-Bromo-4-Fluorobenzene as a building block. Its dual halogen profile makes it a sought-after raw material for Suzuki or Stille coupling reactions. Researchers use it for the introduction of tailored fluorinated and brominated rings in target molecules, which is fundamental in the design of drug candidates and small-molecule materials for advanced technology. Firms that deal with organic synthesis value the precise pattern of substitution for structure-activity relationship studies, where subtle shifts in chemical properties can drive whole research and development efforts.
Labs monitor the density of 1-Bromo-4-Fluorobenzene since it relates directly to purity and identity. Measured near 1.55 g/cm³, this density falls in line with similar halogenated aromatics. In the field or at production scale, technicians encounter it primarily as a liquid, though crystallization can occur under low temperature storage conditions. Storage and transfer follow standard protocols for aromatic chemicals, mitigating flammability risk and accidental exposure. Its weight and state help determine batching for chemical reactions or packaging for international transit.
Anyone handling 1-Bromo-4-Fluorobenzene needs to recognize key safety concerns. The compound ranks as harmful if swallowed, inhaled, or making contact with skin. Its vapors can cause eye and respiratory irritation, and improper handling raises organic solvent exposure risks. Laboratories work with fume hoods and strict personal protective gear, including gloves, goggles, and lab coats, to minimize accidental harm. Fire departments list it as flammable at higher temperatures, requiring careful storage away from ignition sources. Proper labeling and ventilation form part of every risk management plan, especially for those tasked with storage for industrial supply.
Customs and export authorities assign 1-Bromo-4-Fluorobenzene the Harmonized System (HS) Code 2903.69. This code covers halogenated derivatives of benzene, which streamlines international trade routing and regulatory oversight. Bulk shipments head out in compliance with local chemical safety regulations, including hazard communication, spill control schemes, and accurate manifesting. Chemical distributors know that precise classification under the HS Code supports smooth customs clearance and prevents delays at borders.
Researchers running spectroscopic or chromatographic analysis find the molecular profile of 1-Bromo-4-Fluorobenzene features distinct signals: aromatic protons slightly shifted by electron-withdrawing halogen groups, characteristic carbon and fluorine resonances, and a sharp IR signature for halogenated benzene. These properties aid in rapid verification and quality assurance testing. Manufacturers that strive for ultra-pure standards put these analytical handles to work in control labs, ensuring that every batch meets strict requirements whether destined for further synthesis or as a material for specialty blends.
Production-scale 1-Bromo-4-Fluorobenzene gets packed and shipped as a pure liquid; smaller lots might solidify, forming crystals or flakes under cool storage. Some suppliers offer material as a dilute solution tailored for direct addition to chemical reactors, reducing the handling steps in a busy facility. The supply chain demands reliable packaging that prevents leaks, protects against light degradation, and allows for accurate measurement during batch preparation.
Regulatory bodies classify 1-Bromo-4-Fluorobenzene as a hazardous chemical, reminding companies of the duty to maintain rigorous storage and handling protocols. Routine safety training, accessible spill kits, and well-marked containers play the largest roles in preventing workplace injuries. Firms investing in sustainable chemistry keep an eye on minimizing emissions and accidental releases, understanding the environmental persistence of halogenated aromatics. Frequent audits and emergency drills help crews stay ready for the moment something goes wrong, which protects workers, neighbors, and the wider environment.
R&D groups seek greener manufacturing routes both upstream and downstream of 1-Bromo-4-Fluorobenzene. Catalytic methods that cut out toxic byproducts, plus continuous monitoring for leaks and emissions, keep risks manageable. Chemical suppliers who supply literature, data sheets, and safety certificates in clear language find more customers ready to trust their products and processes. Up-to-date automation of weighing, dispensing, and mixing reduces the window for operator error during scale-up projects. Peer-reviewed safety and risk data, made public and updated, enables entire industries to handle this material with higher confidence.
