Product Name: N-Methylaniline
Synonyms: N-Methylbenzenamine, Monomethylaniline
Chemical Formula: C7H9N
Molecular Weight: 107.15 g/mol
CAS Number: 100-61-8
Recommended Use: Industrial chemical, dye intermediate, chemical research
Supplier Details: Contact details for supplier or manufacturer available on invoice or label
Emergency Contact: Local poison control center or emergency response number printed on the container
UN Number: 2294
Hazard Classification: Acute toxicity (oral, dermal, inhalation), skin irritation, eye irritation, suspected carcinogen, hazardous to aquatic life
GHS Label Elements: Skull and crossbones symbol, exclamation mark, aquatic environment symbol
Signal Word: Danger
Hazard Statements: Toxic if swallowed, toxic in contact with skin, toxic if inhaled, causes skin and eye irritation, may cause genetic defects, suspected of causing cancer, harmful to aquatic organisms with long-lasting effects
Precautionary Statements: Avoid breathing dust, vapors, or mist; use protective clothing; wash contaminated skin thoroughly after handling; keep container tightly closed; dispose of contents according to regulations
Routes of Exposure: Inhalation, ingestion, skin absorption, eye contact
Chemical Name: N-Methylaniline
Concentration: 98% - 100% pure (industrial grade can include trace solvents or impurities)
CAS Number: 100-61-8
Inhalation: Move to fresh air immediately, support respiration as needed, seek medical attention for symptoms like coughing, dizziness, or difficulty breathing
Skin Contact: Remove contaminated clothing, wash affected skin with soap and water for at least 15 minutes, do not use solvents or alcohol-based rinses, contact physician for persistent irritation or chemical burns
Eye Contact: Rinse immediately with lukewarm water for at least 15 minutes, hold eyelids apart, remove contact lenses if present and easy to do, consult ophthalmologist if irritation continues
Ingestion: Rinse mouth thoroughly, do not induce vomiting, give water only if person is fully conscious, seek immediate medical attention
Most Important Symptoms: Nausea, headache, cyanosis (bluish skin), respiratory distress, skin discoloration signaling methemoglobinemia, confusion
Advice for Medical Staff: Monitor for methemoglobinemia, administer oxygen, monitor vital signs, provide symptomatic treatment and supportive care
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical powder, carbon dioxide, water spray to cool fire-exposed containers
Unsuitable Media: Direct water jet may spread fire
Fire Hazards: Flammable liquid and vapor, forms explosive mixtures with air, releases toxic nitrogen oxides, carbon monoxide, and hydrocarbons upon combustion
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Special Procedures: Prevent runoff from entering drains or watercourses, stay upwind, remove containers from fire area if it can be done safely
Explosion Sensitivity: Vapors heavier than air can travel to distant ignition sources and flashback
Personal Precautions: Immediately evacuate area of unprotected personnel, ventilate enclosed spaces, wear appropriate personal protective equipment including gloves, goggles, and chemical-resistant clothing
Environmental Precautions: Prevent spill from entering drains, soil, waterways, or sewers, notify relevant authorities in case of major spill or release
Containment Methods: Dike spilled liquid to prevent spreading, use inert absorbent material like sand, earth, or commercially available spill pads
Cleanup Methods: Gather absorbed material and place in suitable chemical waste container for disposal, wash spill site after material is picked up, ventilate area thoroughly before reentry
Handling Precautions: Avoid all direct contact with liquid or vapor, use only in well-ventilated areas with fume extraction, prohibit smoking and open flames near use area, prevent static discharge by means of grounding and bonding containers
Safe Storage: Store in tightly closed containers away from light, heat sources, sparks, and incompatible chemicals (oxidizers, strong acids, strong bases), keep in a dedicated chemical storage cabinet or flammable liquid locker
Storage Temperature: Keep at ambient temperature, avoid excessive heat or cold
Incompatibilities: Oxidizing agents, nitrates, strong acids, acyl halides
Occupational Exposure Limits: No specific OSHA or ACGIH limits established for N-methylaniline; handle as hazardous material and control vapor exposure
Engineering Controls: Use local exhaust ventilation, chemical fume hoods, and explosion-proof equipment, ensure eyewash stations and safety showers in immediate work area
Personal Protective Equipment: Chemical splash goggles, face shield as needed, gloves made from nitrile or neoprene, chemical-resistant apron or coveralls, closed-toe shoes
Respiratory Protection: In case of insufficient ventilation, use organic vapor respirator or Self-Contained Breathing Apparatus (SCBA) where concentrations exceed recommended levels
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing and launder before reuse, do not eat, drink, or smoke in work area
Appearance: Colorless to pale yellow liquid
Odor: Characteristic aromatic, amine-like odor
Odor Threshold: Not readily established
pH: Not applicable (non-aqueous solution)
Melting Point: -57 °C
Boiling Point: Approximately 196 °C
Flash Point: 76 °C (closed cup)
Evaporation Rate: Not established
Flammability: Flammable
Explosive Limits: Lower: 1.3%, Upper: 7.7% (as vapor in air)
Vapor Pressure: 0.4 mmHg at 20 °C
Vapor Density: 3.7 (air=1)
Relative Density: 0.98 g/cm³ at 20 °C
Solubility: Slightly soluble in water, readily soluble in most organic solvents (ethanol, ether, benzene)
Partition Coefficient (log Kow): 1.9
Autoignition Temperature: 482 °C
Decomposition Temperature: Not reported
Viscosity: Not determined
Chemical Stability: Stable under recommended handling and storage conditions, sensitive to light, prolonged exposure can trigger discoloration and slow decomposition
Hazardous Reactions: Reacts with oxidizers, acids, and acylating agents, forming hazardous products such as nitrosamines
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, toxic organic compounds
Conditions to Avoid: Heat, sparks, open flames, sunlight, static discharge, direct contact with incompatible materials
Polymerization: Not known to polymerize
Acute Toxicity: LD50 oral (rat): 346 mg/kg; LD50 dermal (rabbit): 410 mg/kg; moderate to high systemic toxicity by ingestion, skin, or inhalation
Symptoms of Exposure: Irritation of skin, eyes, and mucous membranes, headache, dizziness, cyanosis, confusion, convulsions, respiratory depression
Chronic Toxicity: Repeated or prolonged exposure may cause effects on blood (methemoglobinemia), liver, kidneys, and central nervous system
Carcinogenicity: Not classifiable as to human carcinogenicity but amine derivatives can form N-nitroso compounds, possible cancer risk with chronic exposure
Mutagenicity: Evidence for genetic defects exists from animal studies
Reproductive Effects: Not adequately studied
Other Health Hazards: Absorption through skin can cause systemic poisoning, chemical burns possible on direct contact
Aquatic Toxicity: Moderately toxic to aquatic organisms, LC50 (fish, 96h): 100-200 mg/L, causes long-term effects in aquatic environments
Persistence and Degradability: Biodegradation expected but moderate, persists longer with high loading rates
Bioaccumulative Potential: Moderate with potential for accumulation in aquatic organisms
Mobility in Soil: Limited mobility, binds to organic matter, can contaminate groundwater in case of spills
Other Adverse Effects: Harmful to aquatic flora and fauna, potential disruption to aquatic food webs with repeated releases
Waste Treatment Methods: Dispose of surplus and non-recyclable material as hazardous chemical waste in accordance with local, regional, and national regulations
Container Disposal: Triple rinse containers before recycling or disposal, puncture after cleaning to prevent reuse
Recommended Disposal: Incineration in approved facility with proper emissions controls, do not pour down drains, toilets, or into the environment
Special Precautions: Consult licensed hazardous waste contractor for disposal, protect from release to soil and water
UN Number: 2294
UN Proper Shipping Name: N-Methylaniline
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Substance harmful to aquatic environment, mark packages as "Marine Pollutant" as required
Special Transport Precautions: Secure containers upright, protect from physical damage and direct sunlight, carry emergency spill kit during transport, comply with national and international regulations such as IMDG, IATA, DOT, ADR
TSCA Status: Listed on the US TSCA Inventory
DSL/NDSL (Canada): Present
EU REACH: Registered and regulated under European REACH
OSHA Hazard Classification: Toxic and hazardous substance
SARA Title III: Listed under Section 313 (specific reporting required for certain thresholds)
California Proposition 65: Not specifically listed, but may form nitrosamine derivatives which are regulated
WHMIS Classification: D1A (very toxic), D2A (carcinogenic/mutagenic risk), B3 (flammable liquid)
Other Local Regulations: Subject to regional control and worker right-to-know acts; review local and sector-specific guidance before procurement or use
