Product Name: N-Bromosuccinimide
CAS Number: 128-08-5
Synonyms: NBS, Succinbromimide, 1-Bromopyrrolidine-2,5-dione
Recommended Use: Laboratory chemicals, organic synthesis reagent, brominating agent
Manufacturer/Supplier: [Manufacturer contact information required for actual sheet]
Emergency Phone Number: [Local or national contact number for emergencies]
Classification (GHS): Oxidizing solid (Category 3); Acute toxicity, oral (Category 4); Skin irritation (Category 2); Eye irritation (Category 2A); Specific target organ toxicity - single exposure (Category 3)
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes skin and serious eye irritation; May cause respiratory irritation; May intensify fire; oxidizer
Pictograms: Flame over circle, exclamation mark
Precautionary Statements: Avoid breathing dust; Wash hands thoroughly after handling; Wear protective gloves, clothing, eye, and face protection; Keep away from heat, sparks, open flames, and hot surfaces
Other Hazards: Emits toxic fumes of bromine and nitrogen oxides during decomposition or fire conditions; Dust may cause irritation of mucous membranes.
Substance: N-Bromosuccinimide
Chemical Formula: C4H4BrNO2
Purity: Typically >99%
Impurities: Small traces of succinimide or over-brominated products possible depending on supplier specifications and storage conditions
Other Components: No significant stabilizers or additives reported.
Inhalation: Move exposed person to fresh air immediately; if breathing has stopped, start artificial respiration and seek medical attention rapidly; persistent cough or breathing difficulty needs immediate evaluation
Skin Contact: Remove contaminated clothing and wash affected area thoroughly with soap and water; medical attention recommended for persistent irritation, burns, or worsening symptoms
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids to flush thoroughly; contact lenses should be removed if present and easy to do; immediate medical attention advised in the event of redness, pain, or vision problems
Ingestion: Rinse mouth with water; do not induce vomiting; seek immediate medical attention; symptoms may include nausea, vomiting, or abdominal pain
Important Symptoms and Effects: May cause irritation, cough, burning sensation on skin or eyes, shortness of breath, or gastrointestinal upset.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam; direct streams of water may spread the chemical
Special Hazards: Strong oxidizer; intensifies fire risk; decomposes at high temperature to release toxic gases such as bromine, nitrogen oxides, and carbon oxides
Protective Equipment for Firefighters: Firefighters should wear self-contained breathing apparatus with full protective gear; fight fire from upwind
Specific Methods: Keep containers cool with water spray; do not use high-pressure water jets; evacuate all non-essential personnel from risk area.
Personal Precautions: Use appropriate PPE, including chemical-resistant gloves, protective goggles, respirator if significant dusting occurs, and lab coat; avoid breathing dust and avoid contact with skin, eyes, clothes
Environmental Precautions: Prevent spillage from reaching waterways, drains, or soil; inform responsible authorities if environmental contamination occurs
Clean-Up Methods: Ventilate area; scoop up solid material using non-sparking tools; collect in inert, sealable containers for disposal; wash area with water after material removal; avoid generating dust during clean-up; dispose according to local regulations
Decontamination: Contaminated surfaces can be washed with sodium thiosulfate solution to neutralize residues.
Handling: Handle in well-ventilated fume hood; avoid dust formation and contact with incompatible substances (strong reducing agents, organic materials, acids); use tools and equipment that do not produce sparks
Hygiene Measures: Wash hands thoroughly after handling; do not eat, drink, or smoke in areas where this product is used; keep work clothes separate from personal clothing
Storage: Store tightly sealed in original container away from moisture, direct sunlight, sources of ignition, and incompatible materials; store in a cool, dry, and well-ventilated area; container must be clearly labeled and kept upright to prevent leaks
Incompatibilities: Avoid contact with strong acids, bases, reducing agents, and combustible or organic materials.
Exposure Limits: No occupational exposure limits established by ACGIH, OSHA, or NIOSH; always minimize exposure to all chemical dusts
Engineering Controls: Laboratory fume hood; adequate ventilation to control airborne concentrations
Personal Protective Equipment: NIOSH-approved dust respirator if dust is generated; chemical-resistant gloves (nitrile or neoprene); safety goggles or face shield; lab coat or apron resistant to chemical splashes
Environmental Controls: Prevent chemical release into drains or natural waterways; ensure waste is collected and disposed of by qualified handlers.
Appearance: White to off-white powder or crystalline solid
Odor: Slight chlorine or bromine-like odor
Melting Point: 173–175°C (343–347°F)
Boiling Point: Decomposes before boiling
Density: About 2.48 g/cm3
Solubility: Slightly soluble in water; more soluble in ethanol, ether, acetone, and chloroform
pH (1% aqueous): Around 5–6
Vapor Pressure: Not applicable (decomposes)
Molecular Weight: 177.98 g/mol
Other: Stable in a dry, cool place; sensitive to moisture; strong oxidizer.
Chemical Stability: Stable under recommended conditions; decomposes in presence of moisture or high temperatures
Reactivity: Powerful oxidizing agent; reacts with reducing agents, acids, bases, and organic material, sometimes violently
Incompatible Materials: Strong acids, bases, reducing agents, flammable substances, ammonia, and metal powders
Hazardous Decomposition Products: Bromine, nitrogen oxides, and carbon oxides produced during combustion or decomposition
Possibility of Hazardous Reactions: Risk of explosion or fire if mixed with incompatible substances or heated rapidly.
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rat): ~891 mg/kg; moderate acute toxicity
Skin/Eye Irritation: Causes significant irritation and potential for corrosive injury, particularly to eyes
Respiratory Sensitization: Dust inhalation causes cough, sore throat, and may trigger asthma-like symptoms in sensitive individuals
Chronic Effects: Persistent contact may cause dermatitis or cumulative organ effects, though major long-term effects not well documented
Symptoms: Cough, sore throat, redness, pain, eye watering, skin burning and irritation, abdominal pain if ingested
Other Information: Not classified as a carcinogen or reproductive toxin by major regulatory agencies.
Ecotoxicity: Harmful to aquatic organisms; may cause long-term adverse effects in aquatic environments
Persistence and Degradability: Slowly biodegradable, decomposes eventually under environmental conditions; hydrolyzes in water to release bromine ions
Mobility: Low mobility in soil but soluble in organic solvents, may migrate through water if spilled
Bioaccumulation: No significant potential for bioaccumulation in aquatic life anticipated
Other Adverse Effects: Avoid uncontrolled release to the environment; persistent chemical may contribute to local water toxicity.
Waste Disposal Methods: Collect and contain residue in tightly closed, labeled containers; chemical waste must be disposed of as hazardous waste, according to local, regional, and national regulations
Product Disposal: Neutralize small amounts with sodium thiosulfate then flush with water; larger quantities require incineration at licensed facility equipped to handle halogenated compounds
Contaminated Packaging: Containers/packaging must undergo triple rinsing and be offered for safe recycling or disposal in accordance with environmental authority guidelines
Regulatory Requirements: Consult with waste management authorities for specific disposal requirements.
UN Number: UN 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (N-Bromosuccinimide)
Hazard Class: 6.1 (Toxic substances)
Packing Group: III (Medium hazard)
Labels Required: Toxic, oxidizer
Marine Pollutant: No
Special Precautions for User: Protect containers from physical damage and keep away from food and feedstuffs during transport; avoid exposure to moisture.
Labeling: Required hazard symbols and signal word (Warning), risk and precaution phrases according to GHS, OSHA Hazard Communication Standard (29 CFR 1910.1200), CLP (EU) and other regional standards
TSCA Status: Listed on the Toxic Substances Control Act (TSCA) Inventory
REACH Status: Listed in the European Union REACH registration
Other Regulatory Lists: May be subject to state and international reporting requirements; not scheduled by CWC
Workplace Classification: Classified as a hazardous chemical for workplace use; safety training, emergency plans, and safety equipment must be available to workers handling this substance.
