Product Name: Methyl Dichloroacetate
Chemical Formula: C3H4Cl2O2
Synonyms: Dichloroacetic acid methyl ester
CAS Number: 1665-00-5
Recommended Use: Laboratory reagent, chemical synthesis
Supplier: Refer to packaging or invoice for full supplier details
Emergency Contact: Refer to regional chemical emergency numbers or regulatory databases
Classification: Acute Toxicity (Oral, Dermal, Inhalation) – Category 3
Signal Word: Danger
Hazard Statements: Toxic if swallowed, toxic in contact with skin, toxic if inhaled, causes serious eye damage, may cause respiratory irritation, suspected of causing genetic defects
Pictograms: Skull and crossbones, exclamation mark, health hazard
Precautionary Statements: Avoid breathing vapors, wear protective gloves and eye protection, wash thoroughly after handling, use only outdoors or in a well-ventilated area
Chemical Name: Methyl Dichloroacetate
Common Name: Methyl ester of dichloroacetic acid
Concentration: >98% (as supplied in laboratory settings)
Impurities: Trace dichloroacetic acid, residual solvents, moisture content less than 0.5%
Additional Hazardous Components: No additional hazardous components above 0.1%
Inhalation: Remove person to fresh air, keep comfortable for breathing, call poison control center or physician, provide oxygen if breathing is difficult.
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for at least 15 minutes, seek medical attention if irritation or symptoms persist.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek immediate medical attention.
Ingestion: Rinse mouth, do not induce vomiting, call poison control center or physician immediately.
Most Important Symptoms: Respiratory distress, eye and mucous membrane irritation, central nervous system effects
Medical Attention/Special Treatment: Symptomatic and supportive care as needed
Suitable Extinguishing Media: Foam, carbon dioxide, dry chemical, water spray
Unsuitable Media: High-pressure water jet (may spread fire)
Specific Hazards: May form toxic gases (hydrogen chloride, phosgene, carbon monoxide) if involved in fire
Protective Equipment for Firefighters: Self-contained breathing apparatus (SCBA), full protective gear
Special Precautions: Move containers from fire area if it can be done safely; use water spray to cool unopened containers exposed to fire
Personal Precautions: Evacuate area, wear chemical-resistant gloves and eye protection, avoid contact with skin and eyes, ventilate space
Spill Response: Absorb with inert material (sand, vermiculite), transfer to labeled waste container, decontaminate area with soap solution
Environmental Precautions: Do not let material enter drains, waterways, or soil
Clean-Up Procedures: Collect residues, ventilate affected area thoroughly
Handling: Use in well-ventilated area, avoid breathing vapor, wear approved eye and skin protection, avoid ingestion and contact with clothes
Storage: Keep containers tightly closed, store in cool, dry, well-ventilated space away from incompatible substances such as oxidizers, acids, or bases
Incompatibilities: Strong oxidizing agents, strong acids, strong bases
Additional Protection Measures: Ground and bond containers when transferring to prevent electrostatic discharge
Occupational Exposure Limits: No established OSHA, NIOSH, or ACGIH limits for methyl dichloroacetate
Engineering Controls: Use chemical fume hood or local exhaust ventilation system
Personal Protection:
Appearance: Colorless to pale yellow liquid
Odor: Pungent, ester-like
pH: Not applicable
Boiling Point: 135-138°C
Melting Point: -16°C
Flash Point: 45°C (closed cup)
Vapor Pressure: 9 mmHg at 25°C
Solubility: Slightly soluble in water, miscible with organic solvents like ethanol, ether, and chloroform
Density: 1.35 g/cm³ at 20°C
Viscosity: Not available
Partition Coefficient (log Kow): 0.72 (estimated)
Auto-ignition Temperature: 380°C
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: Reacts with strong oxidizers, hydrolyzes slowly with water
Conditions to Avoid: Excessive heat, open flame, sources of ignition, moisture
Materials to Avoid: Strong acids, strong bases, strong oxidizing agents
Hazardous Decomposition Products: Hydrogen chloride, phosgene, carbon monoxide, carbon dioxide
Acute Toxicity: Oral LD50 (rat): 180 mg/kg, Dermal LD50 (rabbit): data not available, Inhalation LC50 (rat): data not available
Potential Health Effects: Inhalation: Toxic, causes respiratory tract irritation, may lead to CNS depression; Skin: Toxic, may be absorbed through skin, causes irritation; Eyes: Severe irritation, possible permanent damage; Ingestion: Toxic if swallowed, causes damage to gastrointestinal tract
Chronic Effects: Suspected carcinogen based on limited animal studies, may cause genetic defects with prolonged/repeated exposure
Sensitization: No reliable data available
Reproductive Toxicity: No conclusive data available
Mutagenicity: Suspected based on in vitro studies
Aquatic Toxicity: Harmful to aquatic life, may produce long-lasting effects in aquatic environments
Persistence and Degradability: Moderately persistent, hydrolyzes slowly in water over time
Bioaccumulative Potential: Low, based on log Kow value
Mobility in Soil: Migrates through soil and groundwater, should be contained and prevented from environmental release
Other Adverse Effects: Contributes to toxic vapor or fume formation in water and soil
Disposal Methods: Incinerate according to local, state, and federal requirements for hazardous waste; do not dispose of in landfill or sewer
Contaminated Packaging: Rinse container thoroughly, offer for recycling if available, dispose of via licensed hazardous waste contractor
Special Precautions: Label and seal hazardous waste packages clearly, keep waste in original container if possible
UN Number: UN 2810
Proper Shipping Name: Toxic liquid, organic, n.o.s. (Methyl Dichloroacetate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Label: Toxic
Marine Pollutant: No
Special Precautions for User: Handle in accordance with hazardous materials regulations, keep material in original container, avoid spills during transit
TSCA Status: Listed on the United States TSCA inventory
REACH: May require registration in the European Union, check current status with ECHA
OSHA Hazard: Classified as hazardous based on acute toxicity
SARA Title III: Not specifically listed, but all hazardous chemicals must be reported if exceeded threshold quantities
California Proposition 65: No known listing, but users should consult most recent regulatory updates
Other State and International Regulations: Subject to requirements under WHMIS in Canada, GHS in most countries
