Product Name: Ethyl Chloroacetate
Chemical Formula: C4H7ClO2
CAS Number: 105-39-5
Synonyms: Chloroacetic acid ethyl ester, Ethyl monochloroacetate
Recommended Use: Intermediate in organic synthesis, pharmaceuticals, herbicides
Supplier Information: Contact details for responsible company or distributor
Emergency Phone Number: Local and available 24 hours
GHS Classification: Acute Toxicity (Oral, Inhalation, Dermal) Category 3, Skin Corrosion/Irritation Category 2, Eye Damage/Irritation Category 1
Signal Word: Danger
Hazard Statements: Toxic if swallowed, toxic in contact with skin, toxic if inhaled, causes severe skin burns and eye damage
Precautionary Statements: Avoid breathing vapor or mist, wear protective gloves, clothing, and eye protection, wash thoroughly after handling, use only outdoors or in a well-ventilated area
Physical Hazards: Flammable liquids, can form explosive mixtures with air
Environmental Hazards: Harmful to aquatic life, potential for long-lasting effects
Chemical Name: Ethyl Chloroacetate
CAS Number: 105-39-5
Concentration: >98% by weight
Impurities: Chloroacetic acid, Ethanol, less than 2%
Inhalation: Remove victim to fresh air, seek immediate medical attention, provide artificial respiration or oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing immediately, rinse skin with plenty of water for no less than 15 minutes, consult a physician
Eye Contact: Rinse cautiously with water for at least 15 minutes, lift eyelids to ensure thorough rinsing, get medical advice as soon as possible
Ingestion: Do not induce vomiting, rinse mouth with water if victim is conscious, seek medical attention promptly, never administer anything by mouth to an unconscious person
Most Important Symptoms: Severe irritation, tissue damage, difficulty breathing, possible central nervous system depression
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam
Hazards From Combustion Products: Production of hydrogen chloride gas, phosgene, carbon monoxide, and carbon dioxide during combustion
Special Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear to prevent skin and eye contact
Specific Firefighting Procedures: Keep containers cool by spraying with water, remove uninvolved material from area if possible
Explosion Risk: Vapors may form explosive mixtures with air, closed containers can rupture under fire conditions
Personal Precautions: Use chemical splash goggles, protective gloves, long-sleeved clothing, avoid inhalation of vapors, evacuate unnecessary personnel
Environmental Precautions: Prevent entry into sewers, surface and ground water, contain spill with inert material
Cleanup Methods: Absorb spill with sand, earth, or vermiculite, place in sealed containers for disposal, ventilate area thoroughly, decontaminate area with sodium bicarbonate solution followed by aqueous ammonia if safe
Handling: Use with adequate ventilation, avoid contact with skin, eyes, and clothing, do not eat, drink, or smoke while handling, wash hands after use
Storage: Store in a tightly closed container, in a cool, dry, well-ventilated area, segregate from incompatible materials such as acids, bases, oxidizing agents, and strong reducing agents
Incompatibilities: Hydroxides, ammonia, alkali metals, strong oxidizers, amines
Safe Packaging Materials: Use corrosion-resistant, sealed containers, with secondary containment to prevent leaks
Exposure Limits: No specific OSHA PEL or ACGIH TLV established, use control methods to reduce airborne levels to the lowest achievable concentration
Engineering Controls: Fume hood, local exhaust ventilation, safety shower and eyewash station in working area
Respiratory Protection: Wear NIOSH-approved full-face air-purifying respirator with appropriate organic vapor cartridges during potential exposure
Skin Protection: Nitrile or butyl rubber gloves, long-sleeved lab coat, chemical-resistant apron
Eye Protection: Chemical safety goggles, face shield
Hygiene Measures: Replace contaminated clothing, wash thoroughly after handling, maintain clean working environment by routine cleaning
Appearance: Colorless to pale yellow liquid
Odor: Strong, pungent, fruity
Odor Threshold: Noticeable at low concentrations
Melting Point: -38°C
Boiling Point: 143–144°C
Flash Point: 41°C (closed cup)
Evaporation Rate: Not recorded
Flammability: Flammable liquid
Vapor Pressure: 5 mmHg at 25°C
Vapor Density: 4.3 (air = 1)
Solubility: Miscible with most organic solvents, limited solubility in water (<2 g/100 ml at 20°C)
pH: Not applicable
Partition Coefficient (log Kow): 1.02
Decomposition Temperature: >144°C
Viscosity: Not determined
Chemical Stability: Stable during normal use and storage, decomposes in presence of moisture
Reactivity: Reacts vigorously with strong bases, nucleophiles, and oxidizing agents
Hazardous Reactions: May liberate toxic and corrosive gases (HCl, phosgene) on contact with water, strong bases, or heat
Polymerization: Not known to occur
Conditions to Avoid: Elevated temperatures, flames, ignition sources, contact with incompatible substances
Incompatible Materials: Alkalis, alcohols, amines, water, acid chlorides
Routes of Exposure: Skin, eyes, ingestion, inhalation
Acute Toxicity: Oral LD50 (rat): 580 mg/kg; Dermal LD50 (rabbit): 430 mg/kg; inhalation LC50 (rat, 4 h): 0.47 mg/l
Chronic Effects: Prolonged or repeated exposure may cause dermatitis, respiratory sensitization, damage to liver or kidneys
Symptoms of Overexposure: Irritation of respiratory tract, coughing, headache, dizziness, nausea, abdominal pain, burns to eyes or skin
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: Not reported in published studies
Reproductive Toxicity: No conclusive data from animal studies
Target Organs: Central nervous system, respiratory system, skin, eyes
Ecotoxicity: Toxic to aquatic organisms, short-term exposure may cause death of fish and daphnia
Persistence and Degradability: Hydrolyzes in water to form ethyl alcohol and chloroacetic acid, which may persist under some conditions
Bioaccumulative Potential: Low (log Kow indicates minor accumulation)
Mobility in Soil: High mobility, risk of groundwater contamination
Other Adverse Effects: Avoid release to environment, legislation may restrict large-scale use close to natural water bodies
Disposal Methods: Dispose of through licensed chemical waste contractor, incinerate in accordance with local, state, and federal regulations
Contaminated Packaging: Triple-rinse, puncture container, dispose of as hazardous waste
Precautions: Do not discharge into drains, surface water, or soil, avoid contact with reactive chemicals in waste stream
Special Instructions: Consult environmental authorities for guidance, use secondary containment during transportation for disposal
UN Number: 2672
UN Proper Shipping Name: Ethyl chloroacetate
Transport Hazard Class: 6.1 (Toxic substance), 3 (Flammable liquid)
Packing Group: II
Labels: Toxic, Flammable
Marine Pollutant: Yes
Special Transport Precautions: Secure containers, avoid heat or direct sun, transport with compatible chemicals only, comply with all applicable DOT, IMDG, IATA, ADR regulations
OSHA (US): Listed as hazardous chemical, subject to workplace labeling and training requirements
SARA Title III (Hazard Categories): Acute health hazard, fire hazard
TSCA Inventory: Listed
EU Classification: T+ (Very toxic), C (Corrosive), N (Dangerous for the environment)
REACH Status: Registered substance
Canada (DSL): Included
Other National Requirements: Subject to chemical safety assessment, additional national or local restrictions may apply depending on intended use
