Chemical Name: Ethanesulfonyl Chloride
Common Synonyms: Ethylsulfonyl chloride, Ethanesulphonic acid chloride
CAS Number: 594-44-5
Molecular Formula: C2H5SO2Cl
Molecular Weight: 128.59 g/mol
Recommended Uses: Intermediate for pharmaceuticals, agrochemicals, dyes
Supplier: Contact manufacturer for sourcing and distribution channels; ensure supplier provides container labeling and traceability
GHS Classification: Corrosive to metals, Skin corrosion/irritation (Category 1B), Serious eye damage (Category 1), Specific target organ toxicity - single exposure (Category 3, respiratory)
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; causes respiratory irritation, harmful if inhaled
Pictograms: Corrosive, exclamation mark
Precautionary Measures: Avoid inhalation of fumes; avoid contact with skin and eyes; wear suitable protective gear
Environmental Risks: Hazardous to aquatic systems; avoid discharge to waterways
Substance: Ethanesulfonyl Chloride
Purity: Typically >98% unless otherwise stated by supplier
Impurities: Trace sulfonic acids, residual chlorinated compounds can be present depending on manufacturing and storage conditions
Inhalation: Remove exposed person to fresh air; provide oxygen if breathing is difficult; seek immediate medical attention
Skin Contact: Flush skin thoroughly with copious amounts of water for at least 15 minutes; remove contaminated clothing; seek medical evaluation
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes while holding eyelids open; medical assessment necessary due to risk of permanent injury
Ingestion: Do not induce vomiting; rinse mouth with water; get prompt medical help due to risk of corrosive injury to mouth, throat, and stomach
Most Important Symptoms: Severe irritation or burns to skin, eyes, lungs; risk of pulmonary edema, bronchospasm, delayed effects
Suitable Extinguishing Media: Use dry chemical, foam, or carbon dioxide; do not use water jets directly on chemical
Fire Hazards: Decomposition releases toxic fumes including HCl, SO2, and possibly phosgene under certain conditions
Special Protective Equipment: Wear self-contained breathing apparatus and full protective clothing
Fire-Fighting Instructions: Keep containers cool with water spray; prevent runoff from entering drains; approach upwind
Additional Hazards: Contact with water releases corrosive fumes
Personal Protection: Evacuate unnecessary personnel; wear full-face protection, chemical resistant gloves, suit; use positive pressure breathing apparatus in confined areas
Spill Cleanup: Ventilate area; absorb residues with inert material like vermiculite or sand, scoop into marked, sealed containers for disposal
Decontamination: Neutralize residues with dilute sodium carbonate or lime before collection; rinse site thoroughly with water after removal
Environmental Precaution: Stop leak at source if safe; prevent spillage from entering drains or natural waters, notify relevant authorities in case of entry
Safe Handling: Work in chemical fume hoods; avoid aerosol generation and breathing vapors; handle with chemically resistant gloves, splash goggles
Storage Conditions: Store in tightly closed, properly labeled containers; keep in cool, dry, ventilated area away from heat or open flame
Incompatible Materials: Water, strong bases, alcohols, amines, strong oxidizers; avoid contact with organics to prevent hazardous decomposition
Special Storage Design: Segregate from acids, oxidizers, and foodstuffs; ensure secondary containment and corrosion-resistant shelving
Engineering Controls: Local exhaust ventilation, chemical fume hoods, closed systems for large-scale handling
Personal Protection: Chemical splash goggles or face shield; gloves (nitrile or neoprene recommended); chemical-resistant suit; respiratory protection for fumes/dust
Respiratory Protection: Where inhalation risks exist, use NIOSH approved respirators with acid gas cartridges or self-contained breathing apparatus
Exposure Limits: No specific occupational exposure limits set by OSHA or ACGIH; minimize all exposure
Hygiene Measures: Remove protective equipment on leaving area; wash hands and face thoroughly after handling
Form: Clear, colorless to pale yellow liquid
Odor: Strong, pungent, irritating odor, reminiscent of sulfur compounds
Melting Point: -43°C
Boiling Point: 167-170°C
Density: 1.296 g/cm³
Solubility: Reacts with water; limited miscibility with non-polar organic solvents
Vapor Pressure: 0.6 mmHg at 20°C
Refractive Index: 1.464
pH (aqueous hydrolysis): Strongly acidic
Flash Point: 64°C (closed cup)
Auto-ignition Temperature: Not readily available; treat as flammable liquid for control
Chemical Stability: Stable in closed containers under cool, dry, inert atmosphere
Decomposition: Reacts violently with water, forming toxic and corrosive hydrogen chloride and sulfur dioxide
Hazardous Polymerization: Will not occur under recommended storage
Incompatible Materials: Water, strong bases, alcohols, amines, oxidizing agents
Conditions to Avoid: Heat, flame, moisture, sources of ignition, strong mechanical shock
Acute Toxicity: Data suggests moderate oral and inhalation toxicity in animal studies; corrosive injury more prominent than systemic absorption
Routes of Exposure: Skin contact, eye contact, inhalation, accidental ingestion
Symptoms: Severe burns to skin, eyes, mucous membranes; coughing, throat and lung irritation; risk of delayed pulmonary effects after inhalation
Chronic Effects: Prolonged or repeated exposure can produce chronic skin irritation, respiratory sensitization
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Mutagenicity/Reproductive Toxicity: No definitive data available; focus on corrosive hazards for workplace protection
Environmental Hazards: Toxic to aquatic organisms due to acidity and release of sulfur compounds
Persistence and Degradability: Rapidly hydrolyzes in water to ethane sulfonic acid and hydrogen chloride; non-persistent in soil and water but hazardous during decomposition
Bioaccumulation: Not expected to bioaccumulate due to high water reactivity and breakdown
Mobility: Readily dissipates and reacts in aqueous environments, but local hotspots can create acute impacts
Special Precautions: Avoid any uncontrolled release to soil, surface, or groundwater
Disposal Methods: Neutralize with dilute sodium carbonate or lime slurry under controlled conditions; collect and dispose via licensed chemical waste contractor
Incineration: Incineration possible only in industrial, chemical-hazard-approved facilities with gas scrubbing
Disposal Precautions: Avoid contact with water during storage and transfer; resist dumping in uncontrolled landfill or sewer
Residual Containers: Rinse thoroughly with neutralizing agents before disposal; comply with local and national hazardous waste regulations
UN Number: 2581
Proper Shipping Name: ETHANESULFONYL CHLORIDE
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Labeling: Corrosive - keep separate from incompatible materials
Environmental Hazards: Marine pollutant; transport in compliance with IMDG, ADR, IATA standards
Special Transport Precautions: Protect containers from physical damage, ensure upright orientation and correct placarding
TSCA Status: Listed on US Toxic Substances Control Act inventory
EU Regulations: Registered under REACH; subject to specific labeling, classification, and usage constraints
OSHA: Subject to hazard communication standards for corrosive chemicals
Other Local/International Guidance: Follow all applicable regulations for storage, packaging, labeling, safe use, and waste handling; check local environmental emissions controls and worker protection laws
Restriction Notes: Industrial and laboratory use only; not for food, drug, or household applications
