Product Name: Citalopram Hydrobromide
Chemical Formula: C20H22BrFN2O
CAS Number: 59729-33-8
Synonyms: Citalopram HBr, (+)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobromide
Recommended Use: Pharmaceutical active ingredient, antidepressant
Manufacturer Contact Information: Provided by supplier on request, includes emergency phone numbers and mailing address
Emergency Overview: Off-white to white crystalline powder, odorless, used under prescription guidance only due to potent pharmaceutical activity
Hazard Classification: Not classified as hazardous under GHS for normal use; may cause irritation to skin, eyes, and respiratory tract
Label Elements: Not a hazardous substance or mixture under GHS classification, but prudent handling is necessary
Potential Health Effects: Inhalation may irritate respiratory tract, ingestion can affect central nervous system, skin contact may cause mild irritation
Warning Statements: May disrupt mood or behavior if mishandled, not intended for uncontrolled or non-medical use
Special Hazards: Avoid handling in high concentrations, and avoid exposure to dust and residue
Citalopram Hydrobromide: 98-100%
Impurities: Trace levels of manufacturing by-products, less than 1% each
Other Ingredients: None intentionally present
Inhalation: Remove affected person to fresh air; provide medical attention if breathing becomes difficult
Skin Contact: Wash skin with plenty of water and soap, remove contaminated clothing
Eye Contact: Rinse eyes gently with water for several minutes, lift eyelids, seek medical help if irritation persists
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical care; monitor for symptoms of overdose or adverse reactions
Note for Physicians: Provide supportive treatment, monitor central nervous system function, and treat according to observed symptoms
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Special Hazards: May emit toxic fumes of nitrogen oxides, fluoride, and hydrogen bromide under fire conditions
Protective Equipment: Firefighters need self-contained breathing apparatus and protective clothing
Recommendations: Evacuate area, avoid inhaling combustion gases, use caution to prevent runoff into drains
Personal Precautions: Wear personal protective equipment including gloves, goggles, and lab coat; avoid dust formation
Environmental Precautions: Prevent entry into sewers, surface water, and soil
Methods for Clean Up: Sweep or scoop up material, place in appropriate waste container for disposal; clean area with water and detergent
Decontamination Procedures: Dispose of cleaning materials safely, wash hands thoroughly upon completion
Handling: Use with adequate ventilation, minimize dust exposure, avoid breathing in powders
Storage: Store in tightly closed containers away from heat, light, and moisture; dedicated pharmaceutical store recommended
Incompatible Materials: Strong oxidizing agents, reducing agents, and acids
Storage Temperature: Standard room temperature (15–25 °C), do not freeze
Special Requirements: Secure access to authorized personnel only, limit direct handling
Occupational Exposure Limits: No formal exposure limit established; minimize airborne concentration in workspace
Engineering Controls: Handle in fume hood or with local exhaust ventilation
Personal Protective Equipment: Wear gloves (nitrile or latex), lab coat, splash-resistant goggles
Hygiene Measures: Do not eat, drink, or smoke while handling; wash hands after use
Workplace Monitoring: Implement periodic monitoring for pharmaceutical dust in air if large scale operations occur
Appearance: Odorless, white to off-white crystalline powder
Molecular Weight: 405.35 g/mol
pH (1% solution): 4.0–5.0
Melting Point: 182–186 °C (decomposes before boiling)
Solubility: Freely soluble in water, soluble in methanol and ethanol, practically insoluble in dichloromethane
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Nonvolatile at ambient conditions
Partition Coefficient (log Kow): 1.05 (octanol/water)
Odor Threshold: Not established
Chemical Stability: Stable under recommended storage and handling conditions
Hazardous Reactions: None expected under normal processing and storage
Conditions to Avoid: Exposure to heat, light, moisture, and incompatible materials
Incompatible Materials: Strong acids, bases, oxidizing and reducing substances
Hazardous Decomposition Products: Nitrogen oxides, hydrogen bromide, carbon oxides, and fluoride compounds if subjected to fire or high temperatures
Acute Toxicity (Oral): Rat LD50 >2,000 mg/kg; data from animal studies
Routes of Exposure: Oral, dermal, ocular, inhalation
Chronic Effects: May cause neurological changes, gastrointestinal upset, or cardiac effects if ingested long term
Symptoms of Exposure: Drowsiness, agitation, tremor, dry mouth, vomiting, confusion, rarely seizures with overdose
Carcinogenicity: No evidence from animal studies or human data to suggest carcinogenic risk
Mutagenicity: Negative in standard genetic toxicity studies
Reproductive Toxicity: Embryotoxic at high doses in animals; data for use during pregnancy should prompt careful risk-benefit assessment
Ecotoxicity: Data limited, not expected to produce acute hazards to aquatic life at environmental concentrations
Persistence and Degradability: Partial biodegradation in wastewater treatment; may persist in natural ecosystems
Bioaccumulative Potential: Low, based on measured partition coefficient
Mobility in Soil: Potential for limited transport, likely to sorb to organic matter
Other Adverse Effects: Must prevent large releases to minimize pharmaceutical contamination of water or soil
Waste Treatment Methods: Dispose of in accordance with local, regional, national, and international regulations as pharmaceutical or chemical waste
Contaminated Packaging: Rinse and dispose of as hazardous waste; avoid reuse
Special Disposal Procedures: Incinerate under controlled conditions if permitted; do not discharge to natural waterways
Waste Transport: Secure, labeled containers direct to approved site
UN Number: Not regulated as dangerous goods for transport by land, air, or sea
Transport Hazard Class: None
Packing Group: None
Labeling Requirements: Pharmaceutical product, handle to prevent spillage and exposure
Special Precautions for User: Limit access, store upright, avoid extreme temperatures during transit
Environmental Hazards: Not classified as marine pollutant; still, prevent accidental release
US Federal Regulations: Not specifically regulated by OSHA, EPA, or TSCA; use according to Good Manufacturing Practice for pharmaceuticals
EU Regulations: Not subject to REACH authorization or restrictions at current volume threshold
Canada: DSL status may not apply, pharmaceutical import/export controls enforced
Other Regulatory Listings: Product use is regulated under medical and controlled substances authorities
Workplace Labelling: Subject to WHMIS or GHS workplace labelling mandates for pharmaceutical handling
Community Right-To-Know: Not listed on SARA Title III section 313
