Product name: Bromo Fluorobenzene
Chemical Formula: C6H4BrF
Synonyms: Bromofluorobenzene; 1-Bromo-2-fluorobenzene; 1-Bromo-4-fluorobenzene
Recommended Use: Laboratory chemicals, solvent, research and development
Supplier: Commonly available from chemical supply companies
Emergency Telephone: Local poison control center or manufacturer emergency contact
Classification: Flammable liquid (Category 3), Acute Toxicity (Category 4, inhalation/dermal), Skin and Eye Irritant (Category 2)
Hazard Statements: Causes serious eye irritation, harmful if inhaled or in contact with skin, may cause respiratory irritation, may form explosive mixtures with air
Pictograms: Exclamation mark, flame
Signal Word: Warning
Precautionary Statements: Avoid breathing vapors, use in a well-ventilated area, wash hands thoroughly after handling, wear protective gloves and eye/face protection, keep away from heat/sparks/open flames/hot surfaces, no smoking, if on skin: wash with plenty of soap and water, immediately call a poison center if feeling unwell
Chemical: Bromo Fluorobenzene
Chemical Formula: C6H4BrF
CAS Number: 460-00-4 (for 1-Bromo-2-fluorobenzene), 461-54-1 (for 1-Bromo-4-fluorobenzene)
Concentration: >98% (typical laboratory reagent purity)
Impurities: Trace halogenated aromatic compounds
Inhalation: Move to fresh air. Seek medical attention if symptoms such as dizziness, coughing, or difficulty breathing occur. Remove contaminated clothing. If breathing stops, give artificial respiration.
Skin Contact: Remove contaminated clothing and thoroughly wash affected skin with water and soap. Seek medical help if irritation develops or persists.
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids to flush thoroughly. Remove contact lenses if present and easy to do. Get medical attention if irritation continues.
Ingestion: Rinse mouth with water. Never give anything by mouth to an unconscious person. Do not induce vomiting unless directed by medical personnel. Call a physician or poison control center promptly.
Suitable Extinguishing Media: Foam, dry chemical powder, carbon dioxide, water spray (use with caution due to risk of spreading combustion).
Unsuitable Extinguishing Media: Direct water jets may scatter and spread fire.
Specific Hazards: Emits toxic fumes under fire conditions, such as hydrogen bromide, hydrogen fluoride, and carbon oxides.
Protective Equipment: Firefighters should wear full protective body gear and self-contained breathing apparatus.
Special Procedures: Cool containers exposed to fire with water spray to prevent pressure buildup and possible explosions. Do not allow firefighting runoff to enter drains or watercourses.
Personal Precautions: Evacuate area, ventilate the affected space, avoid contact with eyes, skin, and clothing, use personal protective equipment including gloves and goggles, ensure proper respiratory protection when vapor exposure may occur.
Environmental Precautions: Prevent further leakage or spillage if safe to do so, do not let chemical enter drains or watercourses, notify authorities if a significant spill has occurred.
Methods for Cleaning Up: Contain and collect spillage with inert material (dry sand or earth), place in closed containers for disposal, wash the spill area with plenty of water, ventilate area and dispose of waste according to regulatory requirements.
Precautions for Safe Handling: Handle in a chemical fume hood, avoid inhalation of vapors, avoid contact with skin and eyes, use appropriate PPE, wash thoroughly after handling, keep away from ignition sources, ground and bond containers when transferring.
Storage Conditions: Store in tightly closed containers in a cool, dry, well-ventilated place, segregate from incompatible substances such as strong oxidizers and bases, store away from heat and open flame, label containers clearly and inspect regularly for leaks or damage.
Exposure Limits: No specific occupational exposure limits established, follow workplace guidelines for similar halogenated aromatic compounds.
Engineering Controls: Use in a well-ventilated area or fume hood, provide eye wash stations and safety showers, maintain adequate general and local exhaust ventilation.
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile), impervious clothing, splash goggles, face shield, use respirators (NIOSH-approved) if vapor inhalation risk exists, remove contaminated clothing immediately and launder before reuse.
Hygiene Measures: Wash hands, face, and any exposed skin before breaks and after handling the product, do not eat, drink, or smoke during handling, keep work area clean and uncluttered.
Appearance: Clear, colorless to pale yellow liquid
Odor: Aromatic, penetrating odor
Odor Threshold: Not established
pH: Not applicable (non-aqueous)
Melting Point/Freezing Point: -17°C to 6°C (varies by isomer)
Boiling Point/Range: 182°C to 188°C
Flash Point: 62°C (closed cup)
Evaporation Rate: Not determined
Flammability: Combustible
Explosive Limits: Not determined
Vapor Pressure: 1 mm Hg at 42°C
Vapor Density: About 6 (air = 1)
Relative Density: 1.6-1.7 g/cm³
Solubility: Insoluble in water, mixes well with organic solvents
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not available
Decomposition Temperature: Not available
Viscosity: Not available
Chemical Stability: Stable under recommended storage conditions, sensitive to moisture and air exposure over long periods.
Reactivity: May react with strong bases, oxidizers, and reducing agents.
Possibility of Hazardous Reactions: May form toxic decomposition products during combustion or thermal decomposition.
Conditions to Avoid: Heat, flames, ignition sources, strong acids, bases, oxidizers.
Hazardous Decomposition Products: Hydrogen bromide, hydrogen fluoride, carbon oxides, possibly other unidentified toxic and/or irritating compounds.
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Harmful if inhaled, irritant to skin, eyes, and respiratory tract; ingestion can cause gastrointestinal upset or severe burns.
Chronic Effects: Prolonged or repeated exposure can lead to dermatitis, respiratory sensitivity, or liver/kidney damage.
Symptoms: Burning sensation, coughing, wheezing, headache, nausea, dizziness, red or dry skin.
Carcinogenicity: No components classified as carcinogenic by ACGIH, IARC, NTP, or OSHA.
Additional Data: No definitive reproductive toxicity or mutagenicity data available for this compound.
Aquatic Toxicity: Toxic to aquatic organisms if released in large quantities; not readily biodegradable.
Environmental Impact: Can cause long-lasting effects in the environment due to persistence and potential for bioaccumulation.
Mobility: Limited due to low solubility in water, volatilization possible under certain conditions.
Persistence and Degradability: Expected to be persistent, slow to degrade under normal environmental conditions.
Bioaccumulative Potential: May accumulate in aquatic life forms.
Other Adverse Effects: Avoid uncontrolled release to environment, handle waste responsibly.
Waste Treatment Methods: Incinerate in a chemical incinerator equipped with afterburner and scrubber, or use a licensed waste disposal contractor.
Disposal of Contaminated Packaging: Dispose of as unused product, rinse containers and dispose of according to local environmental regulations.
Special Precautions: Do not dispose of into the environment, municipal waste, or by pouring down drains.
Legal Compliance: Follow all federal, state, and local regulations regarding disposal of hazardous chemical wastes.
UN Number: UN 1993 (for flammable liquids, n.o.s.; check for specific variant)
Proper Shipping Name: Flammable Liquid, n.o.s. (Bromo Fluorobenzene)
Transport Hazard Class: 3
Packing Group: III
Marine Pollutant: Not classified
Environmental Hazards: May pose hazard to aquatic environment if spilled during shipment
Special Precautions: Ensure containers closed, upright, and properly labeled throughout transport; comply with all regulations covering transport of hazardous materials.
US TSCA: Listed on Toxic Substances Control Act Inventory
EU REACH: Check status for registration; not listed as a Substance of Very High Concern
OSHA: Considered hazardous under OSHA Hazard Communication Standard
SARA (Title III): Not listed as an extremely hazardous substance, subject to reporting requirements if large-scale release
WHMIS (Canada): Classified as hazardous, requires proper labeling and handling procedures
Other Regulations: Local and regional authorities may have additional requirements for chemical storage, use, and disposal.
