Product Name: 5-Bromoindole
Synonyms: 5-Bromo-1H-indole
Recommended Use: Laboratory research and chemical synthesis
CAS Number: 830-48-2
Molecular Formula: C8H6BrN
Molecular Weight: 196.05 g/mol
Manufacturer/Supplier: Chemical supply companies focused on research applications
Emergency Contact: National Poison Control Center or local emergency numbers
GHS Classification: Acute Oral Toxicity Category 4, Eye Irritation Category 2, Skin Irritation Category 2, Specific Target Organ Toxicity (Single Exposure) Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation, causes skin irritation, may cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust or fumes, wash hands thoroughly after handling, wear protective gloves and eye protection, use only outdoors or in a well-ventilated area
Chemical Identity: 5-Bromoindole
Purity: Typically greater than 98%
Impurities: Unreacted starting and halogenated byproducts, trace solvents
Hazardous Components: 5-Bromoindole is the principal hazardous ingredient, no stabilizers or additional substances present in significant amounts
Eye Contact: Rinse thoroughly with water for several minutes, remove contact lenses if present, seek medical attention immediately
Skin Contact: Remove contaminated clothing, wash area with soap and water, consult a physician or seek medical attention if irritation develops
Inhalation: Move to fresh air, keep victim at rest, seek medical help if symptoms do not subside
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by a medical professional, get medical advice promptly
Most Important Symptoms: Irritation to eyes and mucous membranes, skin sensitivity, nausea or headache after exposure
Suitable Extinguishing Methods: Use dry chemical powders, carbon dioxide, or alcohol-resistant foam, avoid water spray directly on burning chemicals
Hazardous Combustion Products: Releases toxic gases such as hydrogen bromide, nitrogen oxides, and carbon oxides upon overheating or combustion
Protective Equipment: Firefighters wear self-contained breathing apparatus and chemical resistant clothing
Specific Hazards: Dust can become airborne and increase fire risk; high heat disturbs stability causing decomposition to hazardous fumes
Personal Precautions: Evacuate unprotected personnel, ventilate area well, put on PPE including gloves, goggles, and suitable respiratory protection
Environmental Precautions: Prevent entry into drains, soil, or waterways by using absorbent barriers or collecting material
Cleanup Methods: Sweep up carefully without creating dust, transfer to labeled waste container, keep area ventilated and clean with detergent solution
Precautions for Safe Handling: Avoid contact with skin, eyes, and clothing, use only in chemical fume hood or well-ventilated environment, handle with dry hands, and use smallest quantity required for experiment
Storage Conditions: Keep container tightly closed in a cool, dry, well-ventilated storage area, separate from incompatible substances such as oxidizing agents and acids
Incompatibility: Avoid strong oxidizers, acids, and bases
Special Requirements: Store away from food items, lock containers when not in use, label containers clearly
Occupational Exposure Limits: No established exposure limits for this chemical, keep air concentrations below 0.1 mg/m³
Engineering Controls: Use fume hood, local exhaust ventilation, closed handling systems
Respiratory Protection: Use NIOSH-approved half-mask respirator with organic vapor cartridge
Skin Protection: Wear chemical-resistant gloves such as nitrile, lab coat, and closed shoes
Eye Protection: Chemical splash goggles and face shield
Hygiene Considerations: Wash hands before eating or drinking, remove contaminated clothing immediately, maintain clean workplace surfaces
Appearance: White to off-white powder
Odor: Slight aromatic odor
Odor Threshold: Not available
pH: Not applicable
Melting Point: 86-90°C
Boiling Point: 297°C at 760 mmHg
Flash Point: >110°C
Evaporation Rate: Negligible
Flammability: Not classified as flammable, but forms combustible dust in air
Vapor Pressure: Below 1 mmHg at 25°C
Solubility: Slightly soluble in water, highly soluble in ethanol, chloroform, DMSO
Partition Coefficient (log Kow): Not determined
Decomposition Temperature: Begins to decompose near melting point
Viscosity: Solid at room temperature
Chemical Stability: Stable under standard laboratory conditions, degraded by prolonged exposure to heat or light
Conditions to Avoid: High temperatures, sources of ignition, moisture, and strong sunlight
Incompatible Materials: Oxidizers such as peroxides, strong acids, strong bases, and other halogenated compounds
Hazardous Decomposition Products: Hydrogen bromide fumes, nitrogen oxides, carbon monoxide upon combustion or thermal decomposition
Polymerization: Not expected to occur
Acute Toxicity: Data limited, estimated LD50 (oral/rat) 200-2000 mg/kg, possible moderate hazard by ingestion and skin contact
Routes of Exposure: Inhalation, ingestion, or skin/eye contact
Symptoms: Irritation to eyes and skin, respiratory tract discomfort, nausea or dizziness if inhaled
Chronic Health Effects: No clear evidence, but long-term handling may cause sensitization or organ effects
Carcinogenicity: Not classified as a carcinogen by NTP, IARC, or OSHA
Mutagenicity: No data available
Reproductive Toxicity: No data available
Sensitization: Rarely can cause allergic reaction with repeated exposure
Ecotoxicity: Expected to be toxic to aquatic organisms in significant concentrations
Persistence and Degradability: Stable in environment, unlikely to readily degrade by natural processes
Bioaccumulative Potential: May accumulate in soil or sediment, limited bioaccumulation in aquatic species possible
Mobility in Soil: Low mobility due to low water solubility, binding to soil and organic matter
Other Adverse Effects: Avoid uncontrolled release to avoid risk to sensitive ecosystems
Waste Disposal: Dispose as hazardous laboratory waste, use licensed chemical disposal service
Container Disposal: Rinse containers with solvent, triple rinse method recommended, dispose in accordance with local regulations
Special Considerations: Cut off all possible routes for discharge to surface water or drains, incineration preferred for large quantities
UN Number: Not assigned
Proper Shipping Name: Laboratory chemical, n.o.s.
Transport Hazard Class: Not regulated under standard international transport codes, still handle with care
Packing Group: Not classified
Environmental Hazards: Could present risk if large spills reach water systems
Special Transport Precautions: Ship in sealed, labeled containers, protect from direct sunlight, handle by trained personnel only
OSHA: Listed under Hazard Communication Standard, material safety data must be available to workers
TSCA Status: Listed on the TSCA Inventory
REACH Status: Not classified as a substance of very high concern
SARA Title III: Not classified as a reportable substance under Sections 302, 304, or 313
State Right-to-Know: Subject to workplace disclosure in some US states, check your state’s specific chemical inventory lists
Other International Regulations: Not controlled under most conventions, still require professional handling and safety training
Labeling Requirements: Follow latest GHS and regional chemical safety standards, provide full risk assessment in workplace documentation
