Product Name: 5-Bromo-2-Chlorobenzoic Acid
Chemical Formula: C7H4BrClO2
CAS Number: 21739-92-4
Recommended Use: Intermediate in pharmaceutical synthesis, research, laboratory reagent
Manufacturer: [Company/Contact info should be added based on local source]
Emergency Contact: [Emergency medical and spill response lines according to supplier info]
Classification: Eye Irritation – Category 2A; Skin Irritation – Category 2; Specific Target Organ Toxicant Single Exposure – Category 3 (respiratory tract irritation); Hazardous to the Aquatic Environment – Acute Category 2
Pictograms: Exclamation mark (GHS07), environment (GHS09)
Signal Word: Warning
Hazard Statements: Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Toxic to aquatic life.
Precautionary Statements: Avoid breathing dust or fumes. Wear protective gloves, eye protection, face protection. Use only outdoors or in a well-ventilated area. Avoid release to the environment. Wash exposed skin thoroughly after handling.
Chemical Name: 5-Bromo-2-Chlorobenzoic Acid
Synonyms: Benzoic acid, 5-bromo-2-chloro-
Impurities: Trace organic and inorganic contaminants, less than 0.1%, specific to batch and supplier
Concentration: 98-100% (as supplied for most laboratory/industrial applications)
General Advice: Move away from exposure area. Remove contaminated clothing.
Eye Contact: Immediately flush with water for at least 15 minutes. Seek medical attention if symptoms persist.
Skin Contact: Wash thoroughly with water and soap. Seek medical advice if skin becomes irritated.
Inhalation: Move person to fresh air. Seek medical help if breathing problems develop.
Ingestion: Rinse mouth. Do not induce vomiting. Seek medical assistance if feeling unwell.
Suitable Extinguishing Media: Use carbon dioxide, dry chemical powder, alcohol-resistant foam, or water spray.
Fire Hazards: Decomposes upon heating to produce toxic bromine, chlorine, and phosgene gas.
Protective Equipment: Firefighters must wear self-contained breathing apparatus and protective clothing.
Special Advice: Move containers away from fire area. Prevent run-off from fire control entering drains or watercourses.
Personal Precautions: Evacuate personnel, wear gloves, goggles, and dust mask. Avoid dust formation and direct contact.
Environmental Precautions: Prevent entry into drains, surface water, or soil. Notify authorities if significant spillage contaminates environment.
Spill Cleanup: Collect dry material using non-sparking tools, place in sealed containers for disposal. Ventilate area and wash spill site after material pickup is complete.
Handling: Work in chemical fume hood if available, keep container tightly closed, avoid breathing dust, avoid contact with eyes, skin, and clothing.
Storage: Store in a tightly sealed container, in cool, dry place, away from heat sources and incompatible substances such as strong bases, oxidizing agents.
Recommended Storage Materials: Polyethylene or glass containers with chemical-resistant seal.
Engineering Controls: Use with local exhaust ventilation.
Personal Protection: Chemical resistant gloves (nitrile or neoprene), safety goggles, laboratory coat, respiratory protection if dust is generated.
Occupational Exposure Limits: No established limits in OSHA/ACGIH databases; minimize exposure by good laboratory practice.
Hygiene Measures: Prohibit eating, drinking, and smoking in the handling area. Wash hands after use, remove contaminated clothing and wash before reuse.
Appearance: White to off-white powder
Odor: Slight, not distinctive
Melting Point: 183-187°C
Boiling Point: Not applicable (decomposes on boiling)
Solubility: Sparingly soluble in water, soluble in organic solvents such as ethanol, acetone, and DMSO
Vapor Pressure: Essentially negligible
pH (1% solution): Acidic (pH approx. 2)
Relative Density: 1.82 g/cm³
Partition Coefficient (Log Kow): Estimated 2.9-3.3
Flash Point: Not determined
Autoignition Temperature: Not determined
Explosive Properties: No data available
Reactivity: Stable under recommended storage conditions
Chemical Stability: Stable at room temperature; degrades on prolonged exposure to light, moisture, or extreme heat
Conditions to Avoid: Heating, sources of ignition, contact with oxidizers or strong bases
Incompatible Materials: Strong oxidizing agents, strong bases, reducing agents
Hazardous Decomposition Products: Hydrogen chloride, hydrogen bromide, phosgene, carbon oxides released under fire conditions
Acute Toxicity: Oral LD50 (rat): Not fully established, estimated > 2000 mg/kg
Skin Corrosion/Irritation: May cause moderate skin irritation
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory or Skin Sensitization: May cause irritation to respiratory tract
Germ Cell Mutagenicity: No data available
Carcinogenicity: No classification data from IARC/OSHA
Reproductive Toxicity: Not established
Target Organ Effects: Respiratory system, skin, and eyes exposed through repeated or prolonged contact
Symptoms: Irritation, redness, coughing, shortness of breath, headache, gastrointestinal discomfort if ingested
Toxicity to Aquatic Life: Toxic to fish and aquatic organisms, estimated LC50 (fish, 96hr): 10-100 mg/L
Persistence and Degradability: May persist in soil, water; slow biodegradation expected
Bioaccumulation Potential: Moderate, based on log Kow estimates
Mobility in Soil: Low to moderate due to weak solubility in water
Other Adverse Effects: May pose longer-term risks to aquatic life through bioaccumulation or sediment binding
Waste Disposal: Treat waste as hazardous chemical according to local, regional, and national regulations.
Recommended Disposal Methods: Incinerate in a chemical incinerator equipped with afterburner and scrubber.
Contaminated Packaging: Dispose of via licensed chemical waste contractor.
Precautions: Do not discharge to sewer systems or watercourses. Consult waste disposal authority for specific recommendations.
UN Number: Not classified as hazardous under UN transport rules for small quantities, check with carrier if transporting larger shipments.
Proper Shipping Name: 5-Bromo-2-Chlorobenzoic Acid
Transport Hazard Class: Not regulated (may be considered hazardous if shipped in large bulk)
Packing Group: Not assigned
Environmental Hazards: Substance hazardous to the aquatic environment, avoid spillage during transport
Transport Precautions: Secure containers to prevent tipping, keep separate from food and animal feed in transit
US TSCA: Listed
EC REACH: Registration required for imports/uses above 1 ton per year
Signal Words and Symbols: GHS07 (Exclamation Mark), GHS09 (Environmental Hazard)
Labelling Requirements: Comply with OSHA hazard communication standard and European CLP Regulation
Other Regulations: Not listed as controlled drug or precursor, not on US SARA or CERCLA lists, may be subject to further local, state, or country-specific legislation related to environmental protection or occupational exposure
