Product Name: 3-Bromopyridine
Synonyms: m-Bromopyridine, Pyridine, 3-bromo-
Chemical Formula: C5H4BrN
Molecular Weight: 158.00 g/mol
CAS Number: 626-55-1
Recommended Use: Intermediate in chemical synthesis, pharmaceutical manufacturing, research applications
Manufacturer: Refer to label or purchase source
Contact Information: Emergency telephone number and address provided by supplier or local emergency services
Hazard Class: Flammable liquid, Acute toxicity (oral, dermal, inhalation), Skin and eye irritant
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Harmful if inhaled, swallowed or absorbed. Causes skin and serious eye irritation. May cause respiratory irritation.
Precautionary Statements: Avoid breathing vapors. Use with proper ventilation. Wear protective gloves, clothing, and eye protection. Keep away from heat and open flame. In case of incident, seek immediate medical attention.
Chemical Name: 3-Bromopyridine
CAS Number: 626-55-1
Concentration: >99%
Impurities: Minimal, based on purity from supplier
Additives: Not applicable
Inhalation: Remove person to fresh air. Keep at rest in a comfortable position. If breathing difficulties occur, seek immediate medical attention.
Skin Contact: Wash thoroughly with plenty of water and soap. Remove contaminated clothing. Prompt medical attention is necessary if irritation persists.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present. Continue rinsing and call medical help.
Ingestion: Rinse mouth. Do not induce vomiting. Seek medical assistance right away.
Symptoms: Coughing, shortness of breath, redness, burning sensation, abdominal discomfort.
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, carbon dioxide (CO2), water spray for cooling containers only
Special Hazards: May produce irritating, toxic fumes (hydrogen bromide, nitrogen oxides, carbon monoxide) when burning
Advice for Firefighters: Wear self-contained breathing apparatus and full protective gear. Prevent run-off from firefighting entering drains or water courses.
Hazardous Combustion Products: Toxic gases including hydrogen bromide, carbon monoxide, and nitrogen oxides
Personal Precautions: Evacuate unnecessary personnel from area. Use personal protective equipment as recommended. Avoid breathing fumes.
Environmental Precautions: Prevent further leakage or spillage if safe. Do not let product enter drains, soil, or surface water.
Methods for Clean-Up: Absorb spilled material with inert absorbent (sand, diatomaceous earth). Place absorbed material in a chemical waste container. Ventilate area. Clean site with water after removal of material.
Handling: Avoid contact with skin, eyes, and clothing. Use only in a chemical fume hood or well-ventilated space. Keep containers tightly closed.
Storage: Store in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible products such as strong oxidizers. Store below recommended temperature and keep out of reach of unauthorized persons.
Engineering Controls: Laboratory fume hoods or effective local exhaust ventilation recommended for all handling. Safety shower and eye wash station must be nearby.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles or face shield, lab coat, and, if needed, a respirator with organic vapor cartridge.
Exposure Limits: No established OSHA, ACGIH, or NIOSH limits for 3-Bromopyridine; treat as hazardous chemical.
Hygiene Measures: Wash hands and face thoroughly after handling. Do not eat, drink, or smoke when handling.
Appearance: Colorless to pale yellow liquid
Odor: Pungent, penetrating
pH: Not determined
Melting Point: -31°C
Boiling Point: 174-176°C
Flash Point: 63°C (closed cup)
Evaporation Rate: Not available
Flammability: Flammable
Upper/Lower Flammability Limits: Not available
Vapor Pressure: 2.7 mmHg at 25°C
Vapor Density: 5.47 (air=1)
Relative Density: 1.63 g/cm³ at 20°C
Solubility: Slightly soluble in water; soluble in common organic solvents
Partition Coefficient (log Kow): 1.87
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Not established
Chemical Stability: Stable under normal storage and handling conditions
Conditions to Avoid: Heat, flames, sparks, static discharge, and contact with incompatible materials
Incompatible Materials: Strong oxidizers, strong acids, strong bases
Hazardous Decomposition Products: Hydrogen bromide, nitrogen oxides, carbon monoxide and carbon dioxide can form when heated or burned
Polymerization: Will not occur under normal conditions
Routes of Exposure: Inhalation, skin, eye, ingestion
Acute Toxicity: Oral LD50 (rat): approx. 500 mg/kg. Data for other routes limited.
Irritation: Causes severe irritation to eyes, skin, respiratory tract
Sensitization: Not reported
Chronic Effects: Long-term data limited; repeated exposure may aggravate asthma, dermatitis
Mutagenicity/Carcinogenicity: No reliable animal studies available; not known to be carcinogenic
Other Health Effects: Central nervous system depression, nausea, headache, dizziness possible in overexposure scenarios
Aquatic Toxicity: Toxic to aquatic organisms. LC50 (fish 96h): estimated 1–10 mg/L
Persistence and Degradability: Not readily biodegradable; may persist in environment under unfavorable conditions
Bioaccumulation: Potential based on partition coefficient
Mobility: Limited mobility in soil due to slight water solubility
Other Adverse Effects: Avoid release to environment; may impact aquatic life if spilled in quantity
Disposal Methods: Incinerate at licensed facility with proper emission controls, or treat as hazardous waste following local environmental regulations
Contaminated Packaging: Triple-rinse and offer clean containers for recycling or dispose as hazardous waste
Special Precautions: Avoid discharge into drains or sewers. Always follow local, regional, and national regulations for disposal of hazardous chemicals.
UN Number: 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (3-Bromopyridine)
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Labels Required: Flammable liquid
Hazards During Transport: Keep containers upright; secure to avoid leaks and spills
Environmental Hazards: Marine pollutant; avoid release into waterways
Special Transport Precautions: Segregate from oxidizers and foodstuffs during transit
OSHA: Classified as hazardous chemical under OSHA regulations
TSCA Status: Listed on TSCA inventory
SARA Title III: Not specifically listed in Section 313, 302, or 304
EPA Hazard Category: Acute health hazard, fire hazard
EU Classification: Xi (Irritant), F (Flammable), N (Dangerous for the environment)
Label Elements: Follow GHS and local labeling rules
Other Regulations: National and regional regulations may apply for workplace and transport
