Product Name: 2-N-Octyl-4-Isothiazolin-3-One
Synonyms: OIT; 2-Octyl-2H-isothiazol-3-one; 2-n-Octyl-3(2H)-isothiazolone
Chemical Family: Isothiazolinones
Molecular Formula: C11H19NOS
CAS Number: 26530-20-1
Recommended Use: Preservative, Biocide for paints, adhesives, detergents, and industrial products
Supplier: Contact your regional distributor for details
Emergency Contact: Local emergency number, Poison Control Center
Classification: Acute Toxicity (Oral, Dermal), Skin Corrosion/Irritation, Eye Damage/Irritation, Aquatic Acute and Chronic Hazard
Signal Word: Danger
Hazard Pictograms: GHS05 (Corrosive), GHS07 (Exclamation Mark), GHS09 (Environment)
Hazard Statements: Causes severe skin burns and eye damage. Harmful if swallowed. May cause an allergic skin reaction. Very toxic to aquatic life with long lasting effects.
Precautionary Statements: Avoid breathing dust, fume, gas, mist, vapors, or spray. Wash hands thoroughly after handling. Contaminated work clothing must not be allowed out of the workplace. Avoid release to the environment. Wear protective gloves, eye and face protection, and protective clothing.
Chemical Name: 2-N-Octyl-4-Isothiazolin-3-One
Synonyms: OIT
Content (%): 95% or higher (formulation dependent)
Impurities: Not specifically identified; may include trace water, minor related isothiazolones
CAS Number: 26530-20-1
EC Number: 247-761-7
Inhalation: Move person to fresh air. Keep warm and at rest. Seek medical attention if symptoms develop.
Skin Contact: Remove contaminated clothing. Wash skin with soap and water for at least 15 minutes. Seek medical attention for persistent irritation or burns.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Immediate medical attention required.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly with water. Immediate medical attention required.
Acute Symptoms: Burns, irritation, respiratory troubles, allergic reactions. Monitor for delayed effects.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Unsuitable Media: High volume water jet.
Specific Hazards: Combustion releases toxic fumes such as sulfur oxides, nitrogen oxides, hydrogen chloride.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
Special Procedures: Use standard procedures for chemical fires. Cool unaffected containers with water spray to prevent pressure build-up.
Personal Protection: Evacuate unprotected individuals. Use gloves, goggles, chemical-resistant clothing, and respiratory protection as needed.
Environmental Precautions: Prevent leakage or spillage into drains, surface water, and soil. Notify appropriate authorities in case of large spills.
Containment: Stop leak if safe to do so. Use absorbent, non-combustible materials (sand, diatomaceous earth).
Clean-Up Methods: Collect material in suitable, labeled, chemical waste containers for disposal. Wash spilled area with detergent and excess water.
Handling: Avoid contact with skin, eyes, and clothing. Use only with adequate ventilation. Do not breathe vapors or mists. Use proper personal protection. Maintain proper chemical hygiene at work.
Storage Conditions: Store in cool, dry, well-ventilated areas. Keep container tightly closed and away from incompatible substances like strong oxidizers and acids. Avoid freezing.
Storage Life: Stable under recommended conditions. Only use original packaging or approved containers.
Incompatible Materials: Strong acids, bases, oxidizing agents.
Control Parameters: No occupational exposure limits established by OSHA, NIOSH, or ACGIH for OIT. Use good workplace practice.
Ventilation: Use local exhaust ventilation or process enclosure to minimize exposure.
Personal Protective Equipment (PPE): Safety goggles, chemical-resistant gloves (nitrile or butyl rubber recommended), long-sleeved lab coats, face shields, and suitable respiratory protection if ventilation is inadequate.
Hygiene Measures: Wash hands and face after handling. Remove and wash contaminated clothing before reuse. Do not eat, drink, or smoke in work area.
Appearance: Pale yellow to amber liquid
Odor: Slight aromatic, pungent odor
pH: Not available in pure form; typically slightly acidic in solution
Melting Point: Around -6°C
Boiling Point: Decomposes before boiling (about 256°C at atmospheric pressure)
Flash Point: Above 110°C (closed cup)
Auto-ignition Temperature: Not determined
Explosive Properties: Not explosive
Vapor Pressure: Very low at 20°C
Density: 1.03–1.07 g/cm³ at 20°C
Solubility: Slightly soluble in water; miscible with organic solvents
Chemical Stability: Stable under recommended handling and storage conditions.
Reactivity: Reacts with strong oxidizing agents, acids, and bases.
Conditions to Avoid: Excessive heat, freezing temperatures, direct sunlight, incompatible materials.
Hazardous Decomposition: Sulfur oxides, nitrogen oxides, hydrogen chloride, various organic byproducts may form on decomposition.
Hazardous Polymerization: Will not occur under normal conditions.
Acute Toxicity: Harmful or toxic by oral, dermal, and inhalation exposure. LD50 (Oral, rat): Approx. 550 mg/kg; LD50 (Dermal, rabbit): Approx. 690 mg/kg
Skin/Irritation: Causes severe burns. Strong irritant, corrosive to skin.
Eye Damage: Serious risk of eye injury and permanent damage.
Respiratory Sensitization: Not confirmed, but may cause coughing and respiratory discomfort.
Skin Sensitization: Sensitizing agent, may cause allergic reactions.
Chronic Effects: Prolonged or repeated exposure may result in dermatitis.
Carcinogenicity: Not classed as carcinogen by IARC, NTP, ACGIH, or OSHA.
Mutagenicity: Not found to be mutagenic in standard tests.
Reproductive Toxicity: No evidence in standard animal studies.
Ecotoxicity: Very toxic to aquatic organisms. LC50 (fish, 96 hr): 0.19 mg/L; EC50 (daphnia, 48 hr): 0.18 mg/L; EC50 (algae, 72 hr): 0.03 mg/L
Persistence and Degradability: Not readily biodegradable. Persists in environment.
Bioaccumulative Potential: May bioaccumulate in aquatic species.
Mobility: Low mobility in soil, binds to sediment and organic matter.
Other Adverse Effects: Releases to water should be avoided. Use containment methods in all applications.
Waste Disposal Methods: Dispose of contents and container in accordance with local, regional, and national laws. Do not empty into drains or natural water bodies.
Product: Treat as hazardous waste. Incinerate under controlled conditions or send to licensed hazardous waste facility.
Contaminated Containers: Empty containers retain product residues. Collect for recovery or disposal by approved contractor.
Precautions: Prevent environmental contamination. Notify environmental authorities in case of large releases.
UN Number: UN 3265
UN Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (2-N-Octyl-4-Isothiazolin-3-One)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: III
Environmental Hazards: Marine pollutant
Transport Precautions: Avoid rough handling, store upright with secure closures, apply hazard labels and documentation.
TSCA (US): Listed
EINECS/ELINCS (EU): Listed under 247-761-7
REACH (EU): Subject to specific restrictions as a biocidal product
OSHA Status: Not regulated as a hazardous chemical but considered acutely toxic and corrosive
WHMIS (Canada): Classified as E (Corrosive material), D2B (Toxic material causing other effects)
Other Regulations: Subject to local, state, and federal environmental and workplace laws regarding hazardous substances. Use under guidelines for toxic and environmentally harmful chemicals. Safety data required in the workplace.
