Product Name: 2-Bromopyridine
Chemical Formula: C5H4BrN
Molecular Weight: 158.00 g/mol
Synonyms: α-Bromopyridine, Pyridine, 2-bromo-
CAS Number: 109-04-6
Recommended Use: Organic synthesis, pharmaceutical intermediates
Supplier: Chemical manufacturing and research suppliers
Emergency Phone: Local poison control center, medical facility, or emergency services
GHS Classification: Acute Toxicity (Oral, Inhalation, Dermal) Category 4, Skin Irritation Category 2, Eye Irritation Category 2A
Label Elements: Warning symbol (Exclamation mark)
Hazard Statements: Harmful if swallowed, in contact with skin, or inhaled. Causes skin irritation and serious eye irritation.
Precautionary Statements: Avoid breathing dust, vapors, or spray; wear protective gloves, clothing, eye and face protection; wash thoroughly after handling.
Potential Health Effects: Eyes: Causes irritation or damage; Skin: Causes irritation; Inhalation: Harmful; Ingestion: Harmful; Target organs: central nervous system, liver, kidneys.
NFPA Rating: Health: 2, Flammability: 1, Reactivity: 0
Chemical Name: 2-Bromopyridine
CAS Number: 109-04-6
Percentage: >99%
Impurities: Trace pyridine derivates may be present in technical grades at low concentrations. Other hazardous components are not expected.
Inhalation: Move affected person to fresh air; give artificial respiration if not breathing; seek immediate medical help.
Skin Contact: Remove contaminated clothing. Rinse skin with water for at least 15 minutes. Seek medical attention if irritation persists.
Eye Contact: Rinse thoroughly for 15 minutes with water, lifting eyelids. Get medical attention right away.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek medical attention or call poison control as soon as possible.
Notes to Physician: Treat symptomatically and supportively. Consider risks of allergic reactions, central nervous system depression, and chemical burns.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide.
Unsuitable Media: Direct water streams on burning liquid may spread fire; avoid.
Hazardous Combustion Products: Hydrogen bromide, nitrogen oxides, carbon oxides.
Firefighter Protection: Wear full-face, self-contained breathing apparatus, and appropriate personal protection.
Special Hazards: Containers risk bursting in intense heat. Toxic vapors might be given off under fire conditions. Stay clear of low-lying vapors.
Personal Precautions: Avoid contact with spilled material, ventilate area, wear chemical-resistant gloves, goggles, protective clothing, and respiratory protection.
Spill Cleanup: Absorb with non-combustible material (sand, earth, vermiculite). Shovel or sweep up, then place in waste containers. Clean spill area thoroughly.
Environmental Precautions: Prevent leakage or spillage into sewers, water sources, or ground.
Notification: Report large releases to relevant authorities according to local regulations.
Handling: Use only in well-ventilated areas. Avoid inhalation and skin or eye contact. Wash hands and face before eating or leaving the work area.
Storage Conditions: Store in a tightly closed, labeled container in a cool, dry, and ventilated place. Keep away from incompatible substances such as strong oxidizers or acids.
Precautions: Do not store or consume food in handling areas. Make sure safety showers and eyewash stations are nearby.
Incompatibilities: Avoid contact with strong oxidizers; can react and cause hazardous conditions.
Occupational Exposure Limits: National or local occupational exposure limits not established specifically for 2-bromopyridine. Control exposure with good laboratory and manufacturing hygiene practices.
Engineering Controls: Use local exhaust ventilation, process enclosures, or other engineering solutions to keep airborne levels below recommended exposure limits.
Personal Protective Equipment (PPE): Chemical splash goggles, chemical-resistant gloves, lab coat or apron, and, in situations of potential exposure above limits, use respirators approved for organic vapors.
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling. Remove contaminated clothing and wash before reuse.
Appearance: Clear to pale yellow liquid
Odor: Pungent, distinctive brominated aromatic odor
Boiling Point: 197°C (387°F)
Melting Point: -16°C (3°F)
Flash Point: 85°C (185°F) closed cup
Evaporation Rate: Not data available
Vapor Density: 5.46 (air=1)
Vapor Pressure: 0.4 mm Hg at 25°C
Solubility: Slightly soluble in water; soluble in ethanol, ether, organic solvents
Density: 1.69 g/cm³
pH: Not applicable
Partition Coefficient (n-octanol/water): 1.36
Autoignition Temperature: No data available
Stability: Stable under ambient conditions in tightly sealed containers.
Polymerization: No risk of hazardous polymerization.
Incompatibilities: Strong oxidizing agents, acids.
Hazardous Decomposition: Under fire or decomposition, generates hydrogen bromide, oxides of carbon, and nitrogen oxides.
Conditions to Avoid: Heat, flame, sparks, moisture, incompatible chemicals.
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion.
Acute Toxicity: LD50 Oral (rat): 316 mg/kg. Harmful if swallowed, inhaled, or in contact with skin.
Skin Corrosion/Irritation: Causes irritation or redness.
Eye Damage/Irritation: Causes significant eye irritation or burns.
Respiratory Sensitization: Possible irritation of nose, throat, and lungs upon inhalation.
Chronic Effects: Prolonged or repeated exposure affects liver, kidneys, central nervous system.
Carcinogenicity: Not listed as a known carcinogen by IARC, NTP, or OSHA.
Other Data: Symptoms of overexposure may include headache, dizziness, nausea, chemical burns.
Ecotoxicity: Harmful to aquatic life with long lasting effects (LC50 for fish, Daphnia, or algae data limited).
Mobility: Expected low mobility in soil. Limited data on environmental persistence.
Bioaccumulation: Has potential for bioaccumulation in aquatic organisms.
Degradability: Not readily biodegradable. Full environmental fate not established.
Other Effects: Significant releases might cause adverse effects in water, soil, or air.
Waste Treatment Methods: Dispose of contents in accordance with local, regional, and national regulations for hazardous waste.
Contaminated Packaging: Rinse thoroughly and offer for recycling or proper disposal through qualified waste contractors.
Residues: Residual chemical may require incineration in hazardous waste furnaces.
Special Precautions: Do not release to the environment. Prevent entry into waterways or drains.
UN Number: 1992
Proper Shipping Name: Flammable Liquid, Toxic, N.O.S. (contains 2-bromopyridine)
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III
DOT/ADR/IATA Regulations: Classified as hazardous for land, air, and sea transport; must be properly labeled and packaged for transit.
Special Precautions: Prevent leakage during transport. Store away from incompatible materials during transit to prevent incidents.
Environmental Hazards: Marine pollutant; avoid releases into the environment during shipping.
Inventory Status: Listed on TSCA (USA), EINECS (EU), DSL (Canada), and similar inventories.
SARA Title III (USA): Does not appear as an Extremely Hazardous Substance, though reporting might be required under Section 313 for certain uses.
OSHA: Regulated under OSHA’s Hazard Communication standard; hazard statements required on labels and Safety Data Sheets.
Right-To-Know Lists: Appears on state lists such as Massachusetts RTK, New Jersey RTK, Pennsylvania RTK.
Other Regulation: Subject to chemical risk assessment and handling standards in many jurisdictions. Users should check all applicable regulations and standards before procurement, use, and disposal.
