Product Name: 1-Propanesulfonyl Chloride
CAS Number: 17618-98-1
Synonyms: Propylsulfonyl chloride, n-Propylsulfonyl chloride
Molecular Formula: C3H7SO2Cl
Molecular Weight: 142.61 g/mol
Recommended Use: Chemical intermediate for pharmaceutical synthesis, agrochemicals, specialty chemicals
Supplier Name: Refer to local supplier for specific contact details
Emergency Contact: Local poison control center or emergency telephone number on transport document
UN Number: UN3265
Product Code: Refer to packaging label
Manufacturing Site: See container label for site and lot number
Classification: Corrosive to skin and eyes, serious eye damage, causes respiratory irritation
GHS Label Elements: Danger, Corrosive pictogram, Exclamation mark
Hazard Statements: Causes severe skin burns and eye damage, may cause respiratory irritation
Precautionary Statements: Avoid breathing vapors or mists, wear protective gloves/eye protection, use only in well-ventilated area, wash thoroughly after handling
Signal Word: Danger
Physical Hazards: Fumes pose inhalation risk, reacts with moisture to release hydrogen chloride gas
Health Hazards: Direct contact may lead to deep tissue injury, exposure through inhalation can cause burning sensation in nasal passages or lungs, may result in delayed pulmonary edema
Environmental Hazards: Harmful to aquatic organisms, risk of hazardous long-term effects in the environment
Chemical Name: 1-Propanesulfonyl Chloride
Chemical Formula: C3H7SO2Cl
Concentration: ≥98% by weight
Impurities: Residual water, traces of hydrochloric acid, unknown organic byproducts from manufacturing process (usually below 1%)
Hazardous Components: None significantly above reporting thresholds except main ingredient
Additional Ingredients: No known additives or stabilizers added intentionally
Inhalation: Move person to fresh air, keep comfortable, remove contaminated clothing, seek immediate medical attention, provide artificial respiration if breathing is absent
Skin Contact: Flush skin with copious water for at least 20 minutes, remove any contaminated clothing, seek immediate medical assistance, do not attempt neutralization with chemicals
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, get medical attention without delay
Ingestion: Rinse mouth, do not induce vomiting, seek medical help immediately, do not give anything by mouth to an unconscious person
Note to Physician: Symptoms may be delayed; treat for chemical burns, pay close attention to respiratory tract, consider bronchospasm management
Suitable Extinguishing Media: Water spray (do not use direct stream), dry chemical, CO2, foam
Unsuitable Extinguishing Media: Avoid water jets as splashing may spread the corrosive liquid
Hazardous Combustion Products: Hydrogen chloride gas, sulfur oxides, chlorinated organic compounds
Protective Equipment for Firefighters: Self-contained breathing apparatus, full body chemical protective suit
Special Precautions: Evacuate area, fight fire from safe distance, prevent runoff to drains, stay upwind, cool containers exposed to fire with water spray only
Explosion Risk: Not known to be explosive, although exothermic reactions with water possible
Personal Precautions: Evacuate unnecessary personnel, wear chemical splash goggles, impervious gloves, full-face respirator or suitable filter mask, flame-resistant clothing
Environmental Precautions: Prevent spillage from entering drains, soil, and water bodies, if safe contain spill with sand or inert material
Methods for Clean-up: Absorb with inert material (dry sand, silica); do not use sawdust or combustible material, place in sealable and labeled chemical waste containers
Additional Advice: Ventilate affected area, control vapors, clean contaminated surfaces with dilute sodium bicarbonate taking care not to cause further chemical reaction
Handling: Always handle in a chemical fume hood or well-ventilated workspace, keep container tightly closed, avoid all contact with skin, eyes, and clothing, avoid inhaling vapor or dust, wash hands and contaminated clothing after use, ensure eyewash stations are immediately accessible
Storage: Keep in cool, dry, well-ventilated place, protect from direct sunlight and incompatible substances, store in original container made from corrosion-resistant material, segregate from bases, oxidizers, alcohols and water sources
Condition to Avoid: Exposure to damp air, humidity, strong bases, oxidizers, and open flames
Incompatible Materials: Strong bases, amines, water, alcohols, strong oxidizing agents, finely divided metals
Occupational Exposure Limits: No established threshold limit value (check local regulatory requirements)
Engineering Controls: Chemical fume hood, process enclosures, local exhaust ventilation
Personal Protective Equipment: Chemical splash goggles, face shield, impervious gloves (nitrile, neoprene, butyl rubber), flame-resistant laboratory coat, full chemical suit for large quantities, dedicated respiratory protection if engineering controls insufficient (filters certified for acid gases and organics)
Hygiene Measures: Wash thoroughly before eating, drinking, or smoking, do not eat or drink in work area, remove and wash contaminated clothing before reuse
Environmental Controls: Prevent material from entering surface water or drains, procedures in place for proper disposal of spills and contaminated materials
Emergency Equipments: Eye wash stations and safety showers accessible within immediate work area
Appearance: Clear to pale yellow liquid
Odor: Pungent, acrid, stinging
Odor Threshold: Not determined
pH: Strongly acidic upon hydrolysis
Melting Point/Freezing Point: approx. -40°C
Boiling Point/Range: approx. 198°C at 760 mmHg
Flash Point: 94°C (open cup, estimated)
Evaporation Rate: Not available
Flammability: Not classified as flammable liquid
Explosion Limits: Not available
Vapor Pressure: 0.27 mmHg at 25°C
Vapor Density: Not determined
Relative Density: estimated 1.23 at 20°C
Solubility in Water: Reacts, generates heat and hydrogen chloride gas
Solubility (other): Miscible with polar organic solvents
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: Data not available, decomposes during hydrolysis
Viscosity: Not determined
Chemical Stability: Stable only in tightly sealed containers under recommended conditions, decomposes in moist air with release of hydrogen chloride
Reactivity: Reacts rapidly with water, alcohols, amines, bases
Conditions to Avoid: Contact with moisture, humidity, incompatible chemicals, elevated temperatures
Incompatible Materials: Strong bases, oxidizers, reducing agents, water, alcohols, alkali metals
Hazardous Decomposition Products: Hydrogen chloride, sulfur oxides, volatile chlorinated organics
Polymerization: Hazardous polymerization not reported
Acute Toxicity: No specific LD50/LC50 data available; based on similar sulfonyl chlorides, considered toxic if inhaled or if in contact with skin
Skin Corrosion/Irritation: Causes severe burns through protein and lipid hydrolysis, rapid tissue damage in contact with skin
Eye Damage/Irritation: Immediate and severe lesions, may lead to irreversible eye damage, vision loss possible
Respiratory Effects: Coughing, choking, shortness of breath, risk of delayed pulmonary edema
Ingestion Effects: Severe corrosive injury to mouth, throat, esophagus, and stomach
Chronic Effects: Repeated or prolonged exposure aggravates existing lung, skin, or eye conditions; sensitization has not been widely reported
Carcinogenicity: Not listed with IARC, NTP, OSHA as carcinogenic
Mutagenicity: No data available
Reproductive Toxicity: No data available
Target Organs: Respiratory system, skin, eyes
Ecotoxicity: Harmful to aquatic life, harmful to fish and microorganisms on accidental release
Persistence/Degradability: Hydrolyzes rapidly to propanesulfonic acid and hydrogen chloride, both potentially acidifying water bodies
Bioaccumulation Potential: Not expected due to rapid hydrolysis
Mobility in Soil: Likely high, but breakdown products may leach into groundwater and acidify soil
Other Adverse Effects: Very acidic reaction products may stress or destroy sensitive organisms in effluent streams, potential to affect nitrification and denitrification bacterial communities
Disposal Methods: Treat as hazardous chemical waste, neutralize cautiously under expert supervision, collect for disposal by licensed chemical waste contractor
Contaminated Packaging: Triple rinse with suitable solvent, treat rinsate and packaging as hazardous waste, crush or puncture and dispose per local regulations
Environmental Precautions: Do not allow to enter drains, surface water, or soil; avoid disposal through municipal sewage
Additional Advice: Compliance with all federal, state, and local waste disposal regulations recommended, hazardous waste code may apply (consult with authorities for code)
UN Number: UN3265
UN Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains 1-Propanesulfonyl Chloride)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II (medium danger)
Marine Pollutant: Not designated; still precaution required to avoid marine exposure
Environmental Hazards: Harmful effect on aquatic environment after spillage possible
Transport Labels: Corrosive label (black/white, UN8)
Special Precautions for Transport: Ensure secure packaging resistant to breakage, ensure effective secondary containment, personnel transporting must wear chemical protection
Regulatory Notes: Driver and handlers to have training for corrosive chemicals, documentation and emergency procedures must be available during transport
OSHA Status: Regulated as hazardous; Corrosive
TSCA Inventory: 1-Propanesulfonyl Chloride listed
EPA SARA Title III: Not listed as Extremely Hazardous Substance or under Section 313; Section 311/312 (Acute Health Hazard)
WHMIS (Canada): Class E: Corrosive material; additional Class D2B: Toxic material causing other toxic effects
REACH Status (EU): Subject to registration; consult ECHA for specific status
GHS Classification: Skin Corrosive Category 1B, Serious Eye Damage Category 1, Specific Target Organ Toxicity (single exposure) Category 3
Labeling Requirements: Corrosive pictogram, hazard statement, precautionary advice
Other Regulations: State and local regulations may impose additional requirements for handling and storage, special disposal considerations, and environmental impact
