Product Name: 1-Bromo-4-Fluorobenzene
Chemical Formula: C6H4BrF
CAS Number: 460-00-4
Synonyms: para-Bromofluorobenzene, 4-Bromo-1-fluorobenzene
Recommended Use: Laboratory chemical, chemical synthesis, research applications
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Chemtrec: Available for transportation emergencies
Intended Uses: Intended for manufacturing, R&D, not for direct human consumption or drug synthesis
GHS Classification: Flammable liquid, Acute toxicity (oral, inhalation, dermal), Skin irritation, Eye irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled, may cause respiratory irritation, causes skin and eye irritation, flammable liquid and vapor
Pictograms: Exclamation mark, flame
Precautionary Statements: Keep away from heat and open flame, avoid breathing vapors, wear protective gloves, use only outside or in a well-ventilated area, wash skin thoroughly after handling, keep container tightly closed
Long-term Effects: Chronic exposure may cause liver and kidney damage, repeated contact can cause dermatitis and de-fatting of the skin
Environmental Hazards: Harmful to aquatic life, can cause long-lasting effects in the environment, runoff from product or rinsate may enter local water systems
Chemical Name: 1-Bromo-4-Fluorobenzene
CAS Number: 460-00-4
Concentration: >99% (pure substance, no significant impurities affecting classification)
Impurities: May contain residual solvents or starting materials from manufacturing, possible trace contaminants
Molecular Weight: 175.00 g/mol
Structure: Monocyclic aromatic with one bromine and one fluorine substituent
Inhalation: Move person to fresh air, keep warm and at rest, seek medical advice if breathing becomes difficult or symptoms persist, give oxygen if available and trained
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, seek medical attention if skin irritation develops or persists
Eye Contact: Flush eyes gently with plenty of water for 15 minutes lifting eyelids, seek medical help if irritation remains, avoid rubbing eyes during rinsing
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel, seek immediate medical assistance, never give anything by mouth to an unconscious person
Notes for Physicians: Provide symptomatic treatment and supportive care, monitor central nervous, liver, and kidney functions
Suitable Extinguishing Media: Use foam, carbon dioxide, dry chemical, or water spray
Hazardous Combustion Products: Produces toxic gases under fire: hydrogen bromide, hydrogen fluoride, carbon oxides
Special Equipment for Firefighters: Wear full protective gear including self-contained breathing apparatus
Advice for Firefighters: Approach fire from upwind, remove containers from fire area if safe, cool exposed containers with water
Unusual Fire Hazards: Vapors may travel along the ground and ignite at distant sources, static discharge can ignite leaked vapors
Flash Point: Approximately 61°C (closed cup, indicative value)
Explosion Limits: Data not fully established, avoid sources of ignition
Personal Precautions: Evacuate area, ventilate, eliminate ignition sources, avoid breathing vapors, use skin and respiratory protection
Environmental Precautions: Prevent run-off into drains, surface waters, soil, inform authorities in case of large spillage
Cleanup Procedures: Absorb spill with inert material like sand or vermiculite, collect in suitable closed containers, wipe surfaces with solvent-soaked pads as necessary, avoid emission of vapors into air
Disposal of Cleanup Materials: Dispose of contaminated absorbent according to local regulations, label containers clearly, clean area with water and detergent for final decontamination
Handling: Keep away from open flames, sparks, electrostatic discharge, use only with adequate ventilation, use spark-proof tools and explosion-proof equipment, avoid contact with skin and eyes, wash thoroughly after handling, keep container tightly sealed
Storage Conditions: Store in a cool, dry, well-ventilated place, keep container upright and tightly closed, segregate from incompatible material like oxidizing agents, store away from heat and direct sunlight, store only in original or approved chemical containers
Specific Use: Laboratory and industrial use only, not intended for domestic or personal use, procedures should match good laboratory chemical hygiene practices
Occupational Exposure Limits: No established OSHA/ACGIH exposure limits for 1-Bromo-4-fluorobenzene, limit airborne concentrations as low as possible
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels low, use fume hoods in laboratory settings
Respiratory Protection: Use approved NIOSH chemical cartridge respirator if ventilation is inadequate
Skin Protection: Wear chemical-resistant gloves (nitrile or neoprene recommended), use laboratory coat or apron, avoid skin contact
Eye Protection: Safety goggles with side shields, face shield for larger splashes or possible vapor exposure
Hygiene Measures: Wash hands before eating, drinking, smoking, after handling the chemical, remove contaminated clothing and wash before reuse
Appearance: Clear to slightly yellowish liquid
Odor: Typical aromatic smell
Odor Threshold: Not available
pH: Not applicable (organic liquid)
Melting Point: -6°C
Boiling Point: 193-195°C
Flash Point: 61°C
Evaporation Rate: Not determined
Flammability: Flammable liquid
Vapor Pressure: Approximately 0.35 mmHg at 25°C
Vapor Density: 6.1 (air=1)
Relative Density: 1.55 g/cm³ at 20°C
Solubility: Insoluble in water, soluble in organic solvents like ether and acetone
Partition Coefficient (log Kow): Estimated above 3 (potential for bioaccumulation)
Auto-ignition Temperature: Not available
Decomposition Temperature: Not specified
Viscosity: Not determined
Chemical Stability: Stable under standard temperature and pressure
Conditions to Avoid: Open flame, high temperatures, hot surfaces, incompatible materials
Incompatible Materials: Strong oxidizers, strong bases, alkali metals, powdered metals
Hazardous Decomposition Products: Forms hydrogen bromide, hydrogen fluoride, and carbon oxides during combustion or thermal decomposition
Polymerization: Does not polymerize under normal conditions
Reactivity: Reacts with metals to liberate hydrogen, may attack certain plastics and elastomers
Likely Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: May cause respiratory, dermal and gastrointestinal irritation, LD50 oral (rat) estimated 500-2000 mg/kg
Skin Corrosion/Irritation: Causes irritation, may cause sensitization with repeated contact
Eye Damage/Irritation: Causes eye irritation, possible temporary conjunctivitis
Respiratory Sensitization: Prolonged exposure can cause inflammation in the respiratory tract, asthma-like symptoms very rare
Chronic Effects: Prolonged exposure can harm liver, kidney, possible central nervous system depression in high concentrations,
Mutagenicity/Carcinogenicity: No known carcinogenic or mutagenic effects for this material, insufficient data for assessment
Reproductive Toxicity: No data available for specific effects
Symptoms: Coughing, dizziness, headache, nausea, skin reddening, eye discomfort
Ecotoxicity: Harmful to aquatic life, acute and chronic aquatic toxicity must be considered when discharging or disposing of this chemical
Persistence and Degradability: Not rapidly biodegraded, persists in soil and surface waters, photolysis and volatilization are slow
Bioaccumulation Potential: High potential for bioaccumulation based on log Kow, can build up in aquatic organisms
Mobility in Soil: Low mobility in soil, will partition into organic phases
Other Adverse Effects: Not expected to deplete ozone, not a greenhouse gas, persistent organic pollutant profile should be monitored under REACH or local rules
Waste Disposal Methods: Dispose of as hazardous waste via licensed chemical waste contractor, incinerate in approved facility, consult local environmental authorities
Contaminated Packaging: Dispose of empty/unrinsed containers as hazardous material, do not reuse packaging, follow all federal/state/local guidelines
Precautions: Prevent migration into groundwater, do not discharge untreated into sewers or surface water, follow all applicable government regulations, include Material Safety Data Sheet with waste shipment
UN Number: 1993
UN Proper Shipping Name: Flammable Liquid, NOS (1-Bromo-4-fluorobenzene)
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III
DOT/IATA/IMDG Labelling: Flammable liquid, keep away from sources of ignition, handle with trained personnel, transport in properly labeled containers
Marine Pollutant: Not listed as marine pollutant but recommended to minimize spillage into ocean and streams
Special Transport Precautions: Keep sealed and upright, separate from food and incompatible substances, obey all regulations
US Federal: Not listed as a hazardous air pollutant under CAA, not subject to CERCLA reporting, not on OSHA specifically regulated carcinogen list, TSCA listed
SARA Title III: Not subject to Section 302, 304, or 313 notification, SARA 311/312: Immediate (acute) and delayed (chronic) hazards
California Prop 65: Not listed
EU Regulations: Not specifically listed in Annex XVII of REACH, but subject to chemical safety assessment, subject to GHS/CLP labelling
Canada: Present on DSL/NDSL inventory
Local Regulation: Requirements may differ; always verify with regional authorities, specific workplace limits may apply
