Product Name: 1,2-Bis(2-Chloroethoxy)Ethane
Chemical Formula: C6H12Cl2O2
Synonyms: Ethane, 1,2-bis(2-chloroethoxy)- ; bis(2-chloroethoxy)ethane
CAS Number: 112-26-5
Recommended Use: Intermediate for organic synthesis, solvent in laboratories, chemical manufacturing processes
Supplier Information: Manufacturer contact details supplied on original packaging, including emergency phone number for hazardous material support
Classification: Acute toxicity (oral, dermal, inhalation), skin irritant, serious eye irritant, suspected carcinogen, environmental hazard
Signal Word: Danger
Hazard Statements: Harmful if swallowed or inhaled. Causes skin and eye irritation. Suspected of causing cancer through repeated exposure. Toxic to aquatic life with long-lasting effects.
Pictograms: Skull and crossbones, exclamation mark, health hazard, environment
Precautionary Statements: Do not breathe vapors, mist, or spray. Use protective equipment. Wash exposed skin after handling. Store locked up and in tightly closed containers.
Chemical Name: 1,2-Bis(2-Chloroethoxy)Ethane
Concentration: >98% by weight
Impurities: Less than 2%, typically traces of unreacted ethylene glycol or by-products from manufacturing not considered hazardous under current OSHA standards
Molecular Weight: 203.07 g/mol
Other Identifiers: EC Number 203-950-6
Inhalation: Move the person to fresh air. Keep at rest. Seek immediate medical attention if symptoms develop, such as difficulty breathing, coughing, or irritation.
Skin Contact: Remove contaminated clothing immediately. Wash affected area with soap and plenty of water for at least 15 minutes. If irritation develops or persists, get medical attention.
Eye Contact: Rinse thoroughly with water for at least 15 minutes, lifting eyelids to ensure complete flushing of the eye. Seek urgent medical help if pain or vision changes remain.
Ingestion: Do not induce vomiting. Rinse mouth with water if the victim is conscious. Never give anything by mouth to an unconscious person. Get medical assistance without delay.
Symptoms: Burning, irritation, redness, coughing, nausea, respiratory discomfort, headache. Symptoms may be delayed after exposure.
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray or fog for larger fires. Avoid using direct streams of water that can spread burning liquid.
Fire Hazards: Vapors form explosive mixtures with air above flash point. Decomposes upon heating to form hydrochloric acid fumes, possibly carbon monoxide, phosgene, and other toxic gases.
Special Protective Equipment: Full firefighting gear and self-contained breathing apparatus. Avoid inhalation of toxic fumes. Prevent run-off from entering drains or watercourses.
Advice for Firefighters: Stay upwind. Remove unaffected containers from danger zone if safe. Use water spray to keep containers cool.
Personal Precautions: Evacuate area. Wear chemical-resistant gloves, goggles, face protection, and impervious clothing. Use properly functioning respirator if ventilation inadequate.
Environmental Precautions: Prevent spillage from reaching drains, surface water, or soil. Contain spill using sand or inert absorbent. Notify local authorities if significant environmental discharge occurs.
Cleanup Methods: Contain and collect spillage in properly labeled containers for disposal. Clean floors and contaminated surfaces thoroughly with water and detergent. Dispose of residues in accordance with national and local regulations.
Other Information: Ventilate area until all vapors dissipate.
Handling: Operate in a well-ventilated area. Use appropriate personal protective equipment at all times. Avoid inhalation of vapors and direct contact with skin and eyes. Do not eat, drink, or smoke during use.
Storage: Store in tightly closed containers, in a cool, dry, and well-ventilated area dedicated for chemicals. Avoid direct sunlight, excessive heat, and sources of ignition. Keep away from incompatible substances, including strong oxidizers, reducing agents, and strong acids.
Storage Stability: Stable under recommended storage conditions. Inspect containers regularly for leaks or signs of corrosion.
Exposure Limits: No established OSHA or ACGIH permissible exposure limits, but minimize exposure to lowest possible levels.
Engineering Controls: Use mechanical exhaust or process enclosure to control airborne concentrations at the source. Emergency eyewash stations and showers required in immediate work area.
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), splash goggles, face shield, laboratory coat, long pants, closed footwear. Approved respirator or supplied-air equipment if risk of inhalation exists.
Hygiene Measures: Remove contaminated clothing promptly, wash hands after handling, avoid direct exposure and always observe standard laboratory safety protocols.
Appearance: Clear, colorless to slightly yellowish liquid
Odor: Faint, ethereal odor
Odor Threshold: Not available
pH: Not applicable (neutral in water, hydrolyzes over time)
Melting Point: -28°C
Boiling Point: 255–260°C
Flash Point: 120°C (closed cup)
Evaporation Rate: Not determined
Flammability: May form combustible vapors above flash point
Vapor Pressure: 0.08 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: 1.26 g/cm³ at 20°C
Solubility: Slightly soluble in water, miscible with most organic solvents
Partition Coefficient (log Kow): 2.1–2.4
Auto-Ignition Temperature: 335°C
Decomposition Temperature: Not specified
Viscosity: Not determined
Chemical Stability: Stable under recommended storage and handling conditions. Decomposes gradually on exposure to heat, light, and moisture.
Reactivity: May slowly hydrolyze in presence of moisture, especially when exposed to strong acids or bases.
Hazardous Reactions: Reacts vigorously with strong oxidizers, alkali metals, and reducing agents.
Decomposition Products: Phosgene, carbon dichloride, hydrochloric acid, and oxides of carbon upon combustion or thermal decomposition.
Incompatible Materials: Strong acids, bases, oxidizing agents, and reactive metals
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: LD50 (oral, rat): 410 mg/kg. LD50 (dermal, rabbit): 1,900 mg/kg. Inhalation: Harmful if inhaled, may cause respiratory tract irritation.
Chronic Effects: Animal studies indicate possible carcinogenicity with repeated exposures. Hepatic and renal effects observed in high-dose experiments. No well-controlled human chronic exposure data.
Skin and Eye Contact: Causes severe irritation, redness, and possible burns.
Sensitization: Not classified as a known sensitizer.
Mutagenicity/Teratogenicity: Data limited; genotoxic effects observed in vitro.
Other Information: Not listed as confirmed human carcinogen by IARC, NTP, or OSHA, though structurally related ethers have raised concern.
Aquatic Toxicity: Highly toxic to aquatic life. EC50 (fish, 96h): 7.4 mg/L.
Persistence and Degradability: Slow to degrade in water. Significant persistence in soil and groundwater due to low solubility.
Bioaccumulation: Moderate potential, with log Kow suggesting some degree of buildup in organisms.
Mobility in Soil: Moderately mobile. Transport through soil to groundwater possible if spilled.
Other Adverse Effects: No data on ozone depletion, but spills may lead to environmental contamination. Effluent treatment should remove bulk contamination before water discharge.
Recommended Disposal: Dispose of contents through licensed hazardous chemical waste incineration facility. Burning generates hazardous vapors including hydrogen chloride and phosgene.
Container Disposal: Triple rinse emptied containers with suitable solvent, then treat as hazardous waste.
Local Disposal Rules: Comply with federal, state, and local regulations concerning disposal. Do not allow material to enter sewers, surface waters, or landfill sites.
Precautions: Prevent skin contact during disposal. Track all wastes within facility manifest system.
Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 1,2-Bis(2-chloroethoxy)ethane)
UN Number: UN 2810
Hazard Class: 6.1 (Toxic substance)
Packing Group: III
Label Requirements: Toxic, Marine Pollutant (if shipped by sea)
Special Precautions: Keep containers secure and upright, prevent movement or impact during transport.
Emergency Response Codes: Emergency schedules from IMDG or ADR to be followed for accidental spillage or exposure in transit.
OSHA Status: Regulated hazardous material under Hazard Communication Standard
TSCA Inventory: Listed in the Toxic Substances Control Act inventory
SARA Title III (Section 313): Not subject to reporting as a listed toxic chemical
RCRA: Identified as hazardous waste when discarded, subject to applicable EPA disposal rules
Other Regulatory Listings: Potential restrictions or controls under local air, water, and hazardous chemical use regulations
Workplace Restrictions: Restricted to trained personnel. Safety Data Sheet must be available at all handling or storage locations by law.
